登録情報 | データベース: PDB / ID: 3wxa |
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タイトル | X-ray crystal structural analysis of the complex between ALG-2 and Sec31A peptide |
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要素 | - Programmed cell death protein 6
- Protein transport protein Sec31A
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キーワード | APOPTOSIS/TRANSPORT PROTEIN / PENTA-EF-HAND PROTEIN / Endoplasmic reticulum / Membrane / Transport / Apoptosis / Calcium Binding / APOPTOSIS-TRANSPORT PROTEIN complex |
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機能・相同性 | 機能・相同性情報
vesicle coat / neural crest formation / COPII-coated vesicle cargo loading / vascular endothelial growth factor receptor-2 signaling pathway / neural crest cell development / COPII vesicle coat / COPII vesicle coating / XBP1(S) activates chaperone genes / endoplasmic reticulum organization / negative regulation of TOR signaling ...vesicle coat / neural crest formation / COPII-coated vesicle cargo loading / vascular endothelial growth factor receptor-2 signaling pathway / neural crest cell development / COPII vesicle coat / COPII vesicle coating / XBP1(S) activates chaperone genes / endoplasmic reticulum organization / negative regulation of TOR signaling / positive regulation of protein monoubiquitination / COPII-mediated vesicle transport / Cul3-RING ubiquitin ligase complex / negative regulation of vascular endothelial growth factor receptor signaling pathway / COPII-coated ER to Golgi transport vesicle / endoplasmic reticulum exit site / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / ubiquitin-like ligase-substrate adaptor activity / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endoplasmic reticulum to Golgi vesicle-mediated transport / protein-membrane adaptor activity / positive regulation of endothelial cell proliferation / MHC class II antigen presentation / positive regulation of endothelial cell migration / apoptotic signaling pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / intracellular protein transport / ER to Golgi transport vesicle membrane / response to calcium ion / positive regulation of angiogenesis / calcium-dependent protein binding / Signaling by ALK fusions and activated point mutants / protein-macromolecule adaptor activity / cellular response to heat / cytoplasmic vesicle / angiogenesis / protein dimerization activity / endosome / intracellular membrane-bounded organelle / calcium ion binding / endoplasmic reticulum membrane / structural molecule activity / perinuclear region of cytoplasm / magnesium ion binding / endoplasmic reticulum / protein homodimerization activity / extracellular exosome / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Protein transport protein SEC31-like / Ancestral coatomer element 1, Sec16/Sec31 / Sec23-binding domain of Sec16 / EF hand / EF-hand / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. ...Protein transport protein SEC31-like / Ancestral coatomer element 1, Sec16/Sec31 / Sec23-binding domain of Sec16 / EF hand / EF-hand / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Programmed cell death protein 6 / Protein transport protein Sec31A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.36 Å |
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データ登録者 | Takahashi, T. / Suzuki, H. / Kawasaki, M. / Shibata, H. / Wakatsuki, S. / Maki, M. |
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引用 | ジャーナル: Int J Mol Sci / 年: 2015 タイトル: Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2 著者: Takahashi, T. / Kojima, K. / Zhang, W. / Sasaki, K. / Ito, M. / Suzuki, H. / Kawasaki, M. / Wakatsuki, S. / Takahara, T. / Shibata, H. / Maki, M. |
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履歴 | 登録 | 2014年7月29日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2015年3月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月22日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.2 | 2023年11月8日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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