登録情報 | データベース: PDB / ID: 3va2 |
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タイトル | Crystal structure of human Interleukin-5 in complex with its alpha receptor |
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要素 | - Interleukin-5
- Interleukin-5 receptor subunit alpha
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キーワード | CYTOKINE/CYTOKINE RECEPTOR / cytokine / eosinophilic / asthma / JAK/STAT / fibronectin III-like (Fn III) domain / canonical cytokine receptor homology module (CRM) / B cell growth / Ig secretion / eosinophils proliferation / cell surface / CYTOKINE-CYTOKINE RECEPTOR complex |
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機能・相同性 | 機能・相同性情報
interleukin-5 receptor activity / regulation of interleukin-5 production / positive regulation of eosinophil differentiation / interleukin-5 receptor binding / interleukin-5-mediated signaling pathway / positive regulation of leukocyte proliferation / inflammatory response to antigenic stimulus / positive regulation of podosome assembly / cytokine receptor activity / positive regulation of immunoglobulin production ...interleukin-5 receptor activity / regulation of interleukin-5 production / positive regulation of eosinophil differentiation / interleukin-5 receptor binding / interleukin-5-mediated signaling pathway / positive regulation of leukocyte proliferation / inflammatory response to antigenic stimulus / positive regulation of podosome assembly / cytokine receptor activity / positive regulation of immunoglobulin production / cytokine binding / Interleukin-3, Interleukin-5 and GM-CSF signaling / Interleukin receptor SHC signaling / positive regulation of B cell proliferation / cytokine activity / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / cytokine-mediated signaling pathway / positive regulation of peptidyl-tyrosine phosphorylation / RAF/MAP kinase cascade / receptor complex / inflammatory response / immune response / external side of plasma membrane / positive regulation of DNA-templated transcription / signal transduction / extracellular space / extracellular region / membrane / plasma membrane類似検索 - 分子機能 : / Interleukin-5 / Interleukin 5 / Short hematopoietin receptor, family 2, conserved site / Short hematopoietin receptor family 2 signature. / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; ...: / Interleukin-5 / Interleukin 5 / Short hematopoietin receptor, family 2, conserved site / Short hematopoietin receptor family 2 signature. / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 Interleukin-5 / Interleukin-5 receptor subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.703 Å |
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データ登録者 | Kusano, S. / Kukimoto-Niino, M. / Shirouzu, M. / Yokoyama, S. |
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引用 | ジャーナル: Protein Sci. / 年: 2012 タイトル: Structural basis of interleukin-5 dimer recognition by its alpha receptor 著者: Kusano, S. / Kukimoto-Niino, M. / Hino, N. / Ohsawa, N. / Ikutani, M. / Takaki, S. / Sakamoto, K. / Hara-Yokoyama, M. / Shirouzu, M. / Takatsu, K. / Yokoyama, S. |
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履歴 | 登録 | 2011年12月28日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2012年7月25日 | Provider: repository / タイプ: Initial release |
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