Entry Database : PDB / ID : 3v7d Structure visualization Downloads & linksTitle Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex ComponentsCell division control protein 4 Protein SIC1 Suppressor of kinetochore protein 1 DetailsKeywords CELL CYCLE / WD 40 domain / phospho-peptide complex / E3 ubiquitin ligase / ligase / phospho binding protein / Sic1 / phosphorylationFunction / homology Function and homology informationFunction Domain/homology Component
RAVE complex / Iron uptake and transport / CBF3 complex / regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / vacuolar proton-transporting V-type ATPase complex assembly / septin ring assembly / nuclear SCF ubiquitin ligase complex / endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ... RAVE complex / Iron uptake and transport / CBF3 complex / regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / vacuolar proton-transporting V-type ATPase complex assembly / septin ring assembly / nuclear SCF ubiquitin ligase complex / endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / regulation of exit from mitosis / kinetochore assembly / regulation of metabolic process / cyclin-dependent protein serine/threonine kinase inhibitor activity / positive regulation of glucose transmembrane transport / protein neddylation / mitotic intra-S DNA damage checkpoint signaling / vacuolar acidification / silent mating-type cassette heterochromatin formation / U3 snoRNA binding / mitochondrial fusion / exit from mitosis / SCF ubiquitin ligase complex / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / negative regulation of macroautophagy / molecular function inhibitor activity / sporulation resulting in formation of a cellular spore / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / Orc1 removal from chromatin / DNA replication origin binding / cullin family protein binding / Antigen processing: Ubiquitination & Proteasome degradation / phosphoserine residue binding / subtelomeric heterochromatin formation / regulation of protein-containing complex assembly / endomembrane system / negative regulation of cytoplasmic translation / regulation of mitotic cell cycle / 90S preribosome / meiotic cell cycle / ubiquitin binding / kinetochore / nuclear matrix / G1/S transition of mitotic cell cycle / G2/M transition of mitotic cell cycle / mitotic cell cycle / ubiquitin-dependent protein catabolic process / protein-containing complex assembly / chromosome, telomeric region / protein ubiquitination / cell division / nucleolus / nucleus / cytoplasm Similarity search - Function Cell division control protein 4, dimerisation domain / Cell division control protein 4 dimerisation domain / F-box domain / Monooxygenase - #50 / A Receptor for Ubiquitination Targets / F-box domain profile. / F-box-like domain superfamily / F-box-like / SKP1 component, dimerisation / S-phase kinase-associated protein 1 ... Cell division control protein 4, dimerisation domain / Cell division control protein 4 dimerisation domain / F-box domain / Monooxygenase - #50 / A Receptor for Ubiquitination Targets / F-box domain profile. / F-box-like domain superfamily / F-box-like / SKP1 component, dimerisation / S-phase kinase-associated protein 1 / SKP1-like, dimerisation domain superfamily / Skp1 family, dimerisation domain / F-box domain / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Monooxygenase / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / SKP1/BTB/POZ domain superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Up-down Bundle / 2-Layer Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Saccharomyces cerevisiae (brewer's yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.306 Å DetailsAuthors Tang, X. / Orlicky, S. / Mittag, T. / Csizmok, V. / Pawson, T. / Forman-Kay, J. / Sicheri, F. / Tyers, M. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2012Title : Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.Authors : Tang, X. / Orlicky, S. / Mittag, T. / Csizmok, V. / Pawson, T. / Forman-Kay, J.D. / Sicheri, F. / Tyers, M. History Deposition Dec 20, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 2, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Jul 17, 2019 Group : Data collection / Derived calculations / Refinement descriptionCategory : software / struct_connItem : _software.classification / _software.name ... _software.classification / _software.name / _software.version / _struct_conn.pdbx_leaving_atom_flag Revision 1.2 Sep 13, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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