登録情報 データベース : PDB / ID : 3uix 構造の表示 ダウンロードとリンクタイトル Crystal structure of Pim1 kinase in complex with small molecule inhibitor 要素Proto-oncogene serine/threonine-protein kinase pim-1 詳細 キーワード TRANSFERASE/INHIBITOR / Pim-1 / leukemia cell lethality / substrate-peptide-binding residue / Fluorescent Correlation Spectroscopy / inhibitor complex / in silico screening / TRANSFERASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins ... positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins / positive regulation of TORC1 signaling / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / nucleolus / negative regulation of apoptotic process / apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ... Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol / Serine/threonine-protein kinase pim-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Parker, L.J. 引用ジャーナル : J.Mol.Biol. / 年 : 2012タイトル : A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide.著者: Tsuganezawa, K. / Watanabe, H. / Parker, L. / Yuki, H. / Taruya, S. / Nakagawa, Y. / Kamei, D. / Mori, M. / Ogawa, N. / Tomabechi, Y. / Handa, N. / Honma, T. / Yokoyama, S. / Kojima, H. / ... 著者 : Tsuganezawa, K. / Watanabe, H. / Parker, L. / Yuki, H. / Taruya, S. / Nakagawa, Y. / Kamei, D. / Mori, M. / Ogawa, N. / Tomabechi, Y. / Handa, N. / Honma, T. / Yokoyama, S. / Kojima, H. / Okabe, T. / Nagano, T. / Tanaka, A. 履歴 登録 2011年11月6日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2012年4月11日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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