登録情報 | データベース: PDB / ID: 3ufl |
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タイトル | Discovery of Pyrrolidine-based b-Secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency |
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要素 | Beta-secretase 1 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / aspartic-type endopeptidase activity / amyloid fibril formation / endosome / endosome membrane / early endosome / lysosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Allison, T. / Munshi, S. / Soisson, S.M. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2012 タイトル: Discovery of pyrrolidine-based beta-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency. 著者: Stachel, S.J. / Steele, T.G. / Petrocchi, A. / Haugabook, S.J. / McGaughey, G. / Katharine Holloway, M. / Allison, T. / Munshi, S. / Zuck, P. / Colussi, D. / Tugasheva, K. / Wolfe, A. / Graham, S.L. / Vacca, J.P. |
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履歴 | 登録 | 2011年11月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年1月18日 | Provider: repository / タイプ: Initial release |
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