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-Structure paper
Title | Discovery of pyrrolidine-based beta-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 240-244, Year 2012 |
Publish date | Nov 1, 2011 (structure data deposition date) |
Authors | Stachel, S.J. / Steele, T.G. / Petrocchi, A. / Haugabook, S.J. / McGaughey, G. / Katharine Holloway, M. / Allison, T. / Munshi, S. / Zuck, P. / Colussi, D. ...Stachel, S.J. / Steele, T.G. / Petrocchi, A. / Haugabook, S.J. / McGaughey, G. / Katharine Holloway, M. / Allison, T. / Munshi, S. / Zuck, P. / Colussi, D. / Tugasheva, K. / Wolfe, A. / Graham, S.L. / Vacca, J.P. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22130130 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3ufl: |
Chemicals | ChemComp-508: ChemComp-SO4: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |