登録情報 データベース : PDB / ID : 3qfb 構造の表示 ダウンロードとリンクタイトル Crystal structure of the human thioredoxin reductase-thioredoxin complex 要素Thioredoxin Thioredoxin reductase 1, cytoplasmic 詳細キーワード OXIDOREDUCTASE / Protein-Protein Complex / Rossmann Fold / Thioredoxin fold / homodimeric pyridine nucleotide disulfide oxidoreductase / electron transport機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Metabolism of ingested MeSeO2H into MeSeH / NADPH peroxidase / NADPH peroxidase activity / Protein repair / Metabolism of ingested H2SeO4 and H2SeO3 into H2Se / cellular detoxification of hydrogen peroxide / positive regulation of peptidyl-cysteine S-nitrosylation / protein-disulfide reductase (NAD(P)H) activity / thioredoxin-disulfide reductase / glutathione-disulfide reductase (NADPH) activity ... Metabolism of ingested MeSeO2H into MeSeH / NADPH peroxidase / NADPH peroxidase activity / Protein repair / Metabolism of ingested H2SeO4 and H2SeO3 into H2Se / cellular detoxification of hydrogen peroxide / positive regulation of peptidyl-cysteine S-nitrosylation / protein-disulfide reductase (NAD(P)H) activity / thioredoxin-disulfide reductase / glutathione-disulfide reductase (NADPH) activity / thioredoxin-disulfide reductase (NADPH) activity / Interconversion of nucleotide di- and triphosphates / negative regulation of protein export from nucleus / Regulation of FOXO transcriptional activity by acetylation / NFE2L2 regulating anti-oxidant/detoxification enzymes / response to nitric oxide / Uptake and function of diphtheria toxin / Detoxification of Reactive Oxygen Species / The NLRP3 inflammasome / mesoderm formation / protein-disulfide reductase activity / positive regulation of DNA binding / Purinergic signaling in leishmaniasis infection / activation of protein kinase B activity / FAD binding / glutathione metabolic process / cell redox homeostasis / TP53 Regulates Metabolic Genes / response to radiation / PPARA activates gene expression / fibrillar center / positive regulation of peptidyl-serine phosphorylation / cellular response to oxidative stress / Oxidative Stress Induced Senescence / cell population proliferation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of transcription by RNA polymerase II / signal transduction / protein homodimerization activity / mitochondrion / RNA binding / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Thioredoxin/glutathione reductase selenoprotein / : / Glutaredoxin / Glutaredoxin / Glutaredoxin domain profile. / Thioredoxin / FAD/NAD-linked reductase, C-terminal dimerisation domain / Pyridine nucleotide-disulphide oxidoreductase, class I, active site / Pyridine nucleotide-disulphide oxidoreductases class-I active site. / Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain ... Thioredoxin/glutathione reductase selenoprotein / : / Glutaredoxin / Glutaredoxin / Glutaredoxin domain profile. / Thioredoxin / FAD/NAD-linked reductase, C-terminal dimerisation domain / Pyridine nucleotide-disulphide oxidoreductase, class I, active site / Pyridine nucleotide-disulphide oxidoreductases class-I active site. / Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain / Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain / FAD/NAD-linked reductase, dimerisation domain superfamily / Thioredoxin / FAD/NAD(P)-binding domain / Pyridine nucleotide-disulphide oxidoreductase / Thioredoxin, conserved site / Thioredoxin family active site. / Enolase-like; domain 1 / Thioredoxin domain profile. / Thioredoxin domain / FAD/NAD(P)-binding domain / FAD/NAD(P)-binding domain / 3-Layer(bba) Sandwich / Glutaredoxin / Glutaredoxin / FAD/NAD(P)-binding domain superfamily / Thioredoxin-like superfamily / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / Thioredoxin / Thioredoxin reductase 1, cytoplasmic 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.6 Å 詳細データ登録者 Fritz-Wolf, K. / Kehr, S. / Stumpf, M. / Rahlfs, S. / Becker, K. 引用ジャーナル : Nat Commun / 年 : 2011タイトル : Crystal structure of the human thioredoxin reductase-thioredoxin complex著者 : Fritz-Wolf, K. / Kehr, S. / Stumpf, M. / Rahlfs, S. / Becker, K. 履歴 登録 2011年1月21日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2011年7月27日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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