regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / positive regulation of synoviocyte proliferation / histamine secretion by mast cell ...regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / positive regulation of synoviocyte proliferation / histamine secretion by mast cell / neutrophil homeostasis / cellular response to molecule of fungal origin / positive regulation of type I hypersensitivity / cellular response to interleukin-7 / MyD88 deficiency (TLR2/4) / MyD88-dependent toll-like receptor signaling pathway / IRAK4 deficiency (TLR2/4) / positive regulation of immunoglobulin production / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / positive regulation of B cell differentiation / positive regulation of NLRP3 inflammasome complex assembly / phospholipase activator activity / negative regulation of interleukin-10 production / B cell activation / negative regulation of B cell proliferation / Fc-epsilon receptor signaling pathway / mesoderm development / phosphatidylinositol-3,4,5-trisphosphate binding / phospholipase binding / RHO GTPases Activate WASPs and WAVEs / positive regulation of B cell proliferation / positive regulation of phagocytosis / cell maturation / FCERI mediated Ca+2 mobilization / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / calcium-mediated signaling / apoptotic signaling pathway / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / Regulation of actin dynamics for phagocytic cup formation / G beta:gamma signalling through BTK / cellular response to reactive oxygen species / peptidyl-tyrosine phosphorylation / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / G alpha (12/13) signalling events / DAP12 signaling / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / ER-Phagosome pathway / cytoplasmic vesicle / G alpha (q) signalling events / protein tyrosine kinase activity / adaptive immune response / Potential therapeutics for SARS / response to lipopolysaccharide / intracellular signal transduction / membrane raft / protein phosphorylation / innate immune response / perinuclear region of cytoplasm / ATP binding / identical protein binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
Resolution: 1.8→94.07 Å / Cor.coef. Fo:Fc: 0.956 / Cor.coef. Fo:Fc free: 0.948 / SU B: 2.488 / SU ML: 0.078 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 0.12 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.213
1323
5.1 %
RANDOM
Rwork
0.183
-
-
-
obs
0.184
26079
-
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
Displacement parameters
Biso mean: 20.75 Å2
Baniso -1
Baniso -2
Baniso -3
1-
0.52 Å2
0.26 Å2
0 Å2
2-
-
0.52 Å2
0 Å2
3-
-
-
-0.78 Å2
Refinement step
Cycle: LAST / Resolution: 1.8→94.07 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
2100
0
62
159
2321
Refine LS restraints
Refine-ID
Type
Dev ideal
Dev ideal target
Number
X-RAY DIFFRACTION
r_bond_refined_d
0.014
0.022
2212
X-RAY DIFFRACTION
r_angle_refined_deg
1.494
1.984
2996
X-RAY DIFFRACTION
r_dihedral_angle_1_deg
10.621
5
263
X-RAY DIFFRACTION
r_dihedral_angle_2_deg
29.729
23.98
98
X-RAY DIFFRACTION
r_dihedral_angle_3_deg
14.245
15
370
X-RAY DIFFRACTION
r_dihedral_angle_4_deg
19.782
15
11
X-RAY DIFFRACTION
r_chiral_restr
0.114
0.2
318
X-RAY DIFFRACTION
r_gen_planes_refined
0.007
0.02
1667
X-RAY DIFFRACTION
r_nbd_refined
0.201
0.2
1044
X-RAY DIFFRACTION
r_nbtor_refined
0.312
0.2
1518
X-RAY DIFFRACTION
r_xyhbond_nbd_refined
0.142
0.2
170
X-RAY DIFFRACTION
r_symmetry_vdw_refined
0.197
0.2
49
X-RAY DIFFRACTION
r_symmetry_hbond_refined
0.218
0.2
15
X-RAY DIFFRACTION
r_mcbond_it
0.965
1.5
1349
X-RAY DIFFRACTION
r_mcangle_it
1.426
2
2106
X-RAY DIFFRACTION
r_scbond_it
2.368
3
1011
X-RAY DIFFRACTION
r_scangle_it
3.495
4.5
890
LS refinement shell
Resolution: 1.8→1.85 Å / Total num. of bins used: 20
Rfactor
Num. reflection
% reflection
Rfree
0.335
85
-
Rwork
0.268
1627
-
obs
-
-
88.75 %
+
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