登録情報 | データベース: PDB / ID: 3n1q |
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タイトル | Crystal Structure of DhhN bound to CDOFn3 |
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要素 | - Cell adhesion molecule-related/down-regulated by oncogenes
- Desert hedgehog protein
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キーワード | PROTEIN BINDING / Binding Sites / Calcium / Cell Adhesion Molecules / Cell Cycle Proteins / Cell Line / Conserved Sequence / Fibronectins / Hedgehog Proteins / Immunoglobulin G / Membrane Glycoproteins / Membrane Proteins / Tertiary / Receptors / Cell Surface / Sequence Homology / Signal Transduction / Tumor Suppressor Proteins |
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機能・相同性 | 機能・相同性情報
skeletal muscle satellite cell differentiation / embryonic body morphogenesis / embryonic retina morphogenesis in camera-type eye / cholesterol-protein transferase activity / HHAT G278V doesn't palmitoylate Hh-Np / regulation of steroid biosynthetic process / Ligand-receptor interactions / Transcriptional regulation of testis differentiation / Activation of SMO / patched binding ...skeletal muscle satellite cell differentiation / embryonic body morphogenesis / embryonic retina morphogenesis in camera-type eye / cholesterol-protein transferase activity / HHAT G278V doesn't palmitoylate Hh-Np / regulation of steroid biosynthetic process / Ligand-receptor interactions / Transcriptional regulation of testis differentiation / Activation of SMO / patched binding / positive regulation of skeletal muscle tissue development / Leydig cell differentiation / self proteolysis / male sex determination / Release of Hh-Np from the secreting cell / myoblast fusion / positive regulation of smoothened signaling pathway / positive regulation of small GTPase mediated signal transduction / Class B/2 (Secretin family receptors) / cell fate specification / lens development in camera-type eye / anterior/posterior pattern specification / smoothened signaling pathway / positive regulation of neuroblast proliferation / Myogenesis / protein autoprocessing / spermatid development / neuroblast proliferation / myelination / positive regulation of neuron differentiation / Hedgehog ligand biogenesis / Hedgehog 'on' state / neuron differentiation / cerebral cortex development / cell-cell adhesion / osteoblast differentiation / response to estrogen / cell-cell signaling / response to estradiol / nervous system development / peptidase activity / regulation of gene expression / positive regulation of MAPK cascade / 加水分解酵素; エステル加水分解酵素 / cell adhesion / positive regulation of protein phosphorylation / Golgi membrane / calcium ion binding / endoplasmic reticulum membrane / positive regulation of transcription by RNA polymerase II / extracellular space / zinc ion binding / plasma membrane類似検索 - 分子機能 Hedgehog, N-terminal signalling domain / Hedgehog protein / Hedgehog protein, Hint domain / Hint module / Hedgehog amino-terminal signalling domain / Muramoyl-pentapeptide Carboxypeptidase; domain 2 - #10 / Muramoyl-pentapeptide Carboxypeptidase; domain 2 / Hedgehog signalling/DD-peptidase zinc-binding domain superfamily / Hint domain C-terminal / Hint (Hedgehog/Intein) domain C-terminal region ...Hedgehog, N-terminal signalling domain / Hedgehog protein / Hedgehog protein, Hint domain / Hint module / Hedgehog amino-terminal signalling domain / Muramoyl-pentapeptide Carboxypeptidase; domain 2 - #10 / Muramoyl-pentapeptide Carboxypeptidase; domain 2 / Hedgehog signalling/DD-peptidase zinc-binding domain superfamily / Hint domain C-terminal / Hint (Hedgehog/Intein) domain C-terminal region / Hint domain N-terminal / Hint (Hedgehog/Intein) domain N-terminal region / Hint domain superfamily / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Desert hedgehog protein / Cell adhesion molecule-related/down-regulated by oncogenes類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.89 Å |
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データ登録者 | Kavran, J.M. / Leahy, D.J. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2010 タイトル: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. 著者: Kavran, J.M. / Ward, M.D. / Oladosu, O.O. / Mulepati, S. / Leahy, D.J. |
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履歴 | 登録 | 2010年5月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年6月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年7月26日 | Group: Database references / Derived calculations カテゴリ: citation / database_2 ...citation / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.3 | 2024年5月22日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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