- PDB-3mxn: Crystal structure of the RMI core complex -
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基本情報
登録情報
データベース: PDB / ID: 3mxn
タイトル
Crystal structure of the RMI core complex
要素
RecQ-mediated genome instability protein 1
RecQ-mediated genome instability protein 2
キーワード
REPLICATION (DNA複製) / Bloom syndrome / helicase (ヘリカーゼ) / RMI / topoisomerase (DNAトポイソメラーゼ) / Replication protein A (DNA複製)
機能・相同性
機能・相同性情報
regulation of sister chromatid segregation / reduction of food intake in response to dietary excess / RecQ family helicase-topoisomerase III complex / resolution of DNA recombination intermediates / maintenance of rDNA / resolution of meiotic recombination intermediates / Impaired BRCA2 binding to PALB2 / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function ...regulation of sister chromatid segregation / reduction of food intake in response to dietary excess / RecQ family helicase-topoisomerase III complex / resolution of DNA recombination intermediates / maintenance of rDNA / resolution of meiotic recombination intermediates / Impaired BRCA2 binding to PALB2 / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / HDR through Single Strand Annealing (SSA) / Impaired BRCA2 binding to RAD51 / negative regulation of double-strand break repair via homologous recombination / Presynaptic phase of homologous DNA pairing and strand exchange / response to glucose / double-strand break repair via homologous recombination / multicellular organism growth / HDR through Homologous Recombination (HRR) / G2/M DNA damage checkpoint / glucose homeostasis / Processing of DNA double-strand break ends / Regulation of TP53 Activity through Phosphorylation / DNA複製 / nuclear body / nuclear speck / nucleotide binding / DNA修復 / DNA binding / 核質 / 細胞核 / 細胞質基質 類似検索 - 分子機能