+Open data
-Basic information
Entry | Database: PDB / ID: 3lxb | |||||||||
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Title | Interconversion of Human Lysosomal Enzyme Specificities | |||||||||
Components | Alpha-galactosidase A | |||||||||
Keywords | HYDROLASE / GLYCOPROTEIN / CARBOHYDRATE-BINDING PROTEIN / GLYCOSIDASE / LYSOSOMAL ENZYME / (BETA/ALPHA)8 BARREL / ENZYME INTERCONVERSION / Disease mutation / Disulfide bond / Lysosome | |||||||||
Function / homology | Function and homology information glycosylceramide catabolic process / negative regulation of nitric-oxide synthase activity / alpha-galactosidase / alpha-galactosidase activity / glycosphingolipid catabolic process / oligosaccharide metabolic process / glycoside catabolic process / galactoside binding / negative regulation of nitric oxide biosynthetic process / Glycosphingolipid catabolism ...glycosylceramide catabolic process / negative regulation of nitric-oxide synthase activity / alpha-galactosidase / alpha-galactosidase activity / glycosphingolipid catabolic process / oligosaccharide metabolic process / glycoside catabolic process / galactoside binding / negative regulation of nitric oxide biosynthetic process / Glycosphingolipid catabolism / catalytic activity / lysosomal lumen / azurophil granule lumen / lysosome / hydrolase activity / signaling receptor binding / Neutrophil degranulation / Golgi apparatus / protein homodimerization activity / extracellular exosome / extracellular region / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 2.85 Å | |||||||||
Authors | Tomasic, I.B. / Metcalf, M.C. / Guce, A.I. / Clark, N.E. / Garman, S.C. | |||||||||
Citation | Journal: J.Biol.Chem. / Year: 2010 Title: Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. Authors: Tomasic, I.B. / Metcalf, M.C. / Guce, A.I. / Clark, N.E. / Garman, S.C. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3lxb.cif.gz | 325.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3lxb.ent.gz | 265.2 KB | Display | PDB format |
PDBx/mmJSON format | 3lxb.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3lxb_validation.pdf.gz | 1.3 MB | Display | wwPDB validaton report |
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Full document | 3lxb_full_validation.pdf.gz | 1.3 MB | Display | |
Data in XML | 3lxb_validation.xml.gz | 30.9 KB | Display | |
Data in CIF | 3lxb_validation.cif.gz | 42.9 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lx/3lxb ftp://data.pdbj.org/pub/pdb/validation_reports/lx/3lxb | HTTPS FTP |
-Related structure data
Related structure data | 3lx9C 3lxaC 3lxcC 3hg3S C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Refine code: 2
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