登録情報 データベース : PDB / ID : 3lfv 構造の表示 ダウンロードとリンクタイトル crystal structure of unliganded PDE5A GAF domain 要素cGMP-specific 3',5'-cyclic phosphodiesterase 詳細 キーワード HYDROLASE / GAF / cGMP signaling機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects ... positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / Smooth Muscle Contraction / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / T cell proliferation / negative regulation of T cell proliferation / cAMP-mediated signaling / metal ion binding / cytosol 類似検索 - 分子機能 GAF domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Domain present in phytochromes and cGMP-specific phosphodiesterases. ... GAF domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Domain present in phytochromes and cGMP-specific phosphodiesterases. / GAF domain / GAF-like domain superfamily / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Beta-Lactamase / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 cGMP-specific 3',5'-cyclic phosphodiesterase 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 多波長異常分散 / 解像度 : 2.8 Å 詳細データ登録者 Wang, H. / Robinson, H. / Ke, H. 引用ジャーナル : J.Biol.Chem. / 年 : 2010タイトル : Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.著者 : Wang, H. / Robinson, H. / Ke, H. 履歴 登録 2010年1月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2010年9月22日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2021年10月13日 Group : Database references / カテゴリ : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details改定 1.3 2024年2月21日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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