- PDB-3l0i: Complex structure of SidM/DrrA with the wild type Rab1 -
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Basic information
Entry
Database: PDB / ID: 3l0i
Title
Complex structure of SidM/DrrA with the wild type Rab1
Components
DrrA
Ras-related protein Rab-1A
Keywords
PROTEIN BINDING/PROTEIN TRANSPORT / GEF-GDF-Rab complex / GTP-binding / guanine-nucleotide exchange factor / GDI-Displacement factor / Type IV effector protein from legionella / PROTEIN BINDING-PROTEIN TRANSPORT complex
Function / homology
Function and homology information
: / protein guanylylation / positive regulation of glycoprotein metabolic process / growth hormone secretion / AMPylase activity / protein adenylyltransferase / protein adenylylation / melanosome transport / COPII-coated vesicle cargo loading / vesicle transport along microtubule ...: / protein guanylylation / positive regulation of glycoprotein metabolic process / growth hormone secretion / AMPylase activity / protein adenylyltransferase / protein adenylylation / melanosome transport / COPII-coated vesicle cargo loading / vesicle transport along microtubule / RAB geranylgeranylation / RAB GEFs exchange GTP for GDP on RABs / host cell cytoplasmic vesicle / Golgi Cisternae Pericentriolar Stack Reorganization / phosphatidylinositol-4-phosphate binding / protein targeting to membrane / COPII-mediated vesicle transport / COPI-dependent Golgi-to-ER retrograde traffic / transport vesicle membrane / regulation of GTPase activity / virion assembly / Golgi organization / autophagosome assembly / endomembrane system / endoplasmic reticulum to Golgi vesicle-mediated transport / COPI-mediated anterograde transport / vesicle-mediated transport / substrate adhesion-dependent cell spreading / small monomeric GTPase / G protein activity / guanyl-nucleotide exchange factor activity / positive regulation of interleukin-8 production / host cell cytoplasmic vesicle membrane / intracellular protein transport / small GTPase binding / autophagy / endocytosis / melanosome / cell migration / protein guanylyltransferase activity / early endosome / defense response to bacterium / cadherin binding / Golgi membrane / GTPase activity / GTP binding / Golgi apparatus / endoplasmic reticulum / extracellular exosome / extracellular region / ATP binding / membrane / cytosol Similarity search - Function
Four Helix Bundle (Hemerythrin (Met), subunit A) - #1520 / de novo design (two linked rop proteins) - #370 / DrrA guanine nucleotide-exchange factor domain / : / : / SidM, Rab1-activation domain / SidM, N-terminal domain / DrrA phosphatidylinositol 4-phosphate binding domain / DrrA, PI4P binding domain superfamily / DrrA phosphatidylinositol 4-phosphate binding domain ...Four Helix Bundle (Hemerythrin (Met), subunit A) - #1520 / de novo design (two linked rop proteins) - #370 / DrrA guanine nucleotide-exchange factor domain / : / : / SidM, Rab1-activation domain / SidM, N-terminal domain / DrrA phosphatidylinositol 4-phosphate binding domain / DrrA, PI4P binding domain superfamily / DrrA phosphatidylinositol 4-phosphate binding domain / : / de novo design (two linked rop proteins) / ARF-like small GTPases; ARF, ADP-ribosylation factor / small GTPase Rab1 family profile. / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Four Helix Bundle (Hemerythrin (Met), subunit A) / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Up-down Bundle / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
Ras-related protein Rab-1A / Multifunctional virulence effector protein DrrA / Multifunctional virulence effector protein DrrA Similarity search - Component
Biological species
Legionella pneumophila (bacteria) Homo sapiens (human)
Method
X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 2.85 Å
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