登録情報 | データベース: PDB / ID: 3kxz |
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タイトル | The complex crystal structure of LCK with a probe molecule w259 |
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要素 | Proto-oncogene tyrosine-protein kinase LCK |
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キーワード | TRANSFERASE (転移酵素) / LCK / Acetylation (アセチル化) / ATP-binding / Cell membrane (細胞膜) / Chromosomal rearrangement / Cytoplasm (細胞質) / Disease mutation / Host-virus interaction / Kinase (キナーゼ) / Lipoprotein (リポタンパク質) / Membrane (生体膜) / Myristate (ミリスチン酸) / Nucleotide-binding / Palmitate (パルミチン酸) / Phosphoprotein / Polymorphism / Proto-oncogene (がん遺伝子) / Tyrosine-protein kinase / Structural Genomics (構造ゲノミクス) / Protein Structure Factory / PSF |
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機能・相同性 | 機能・相同性情報
regulation of lymphocyte activation / positive regulation of leukocyte cell-cell adhesion / Fc-gamma receptor signaling pathway / CD28 co-stimulation / FLT3 signaling through SRC family kinases / intracellular zinc ion homeostasis / CD4 receptor binding / Nef Mediated CD4 Down-regulation / Nef and signal transduction / positive regulation of heterotypic cell-cell adhesion ...regulation of lymphocyte activation / positive regulation of leukocyte cell-cell adhesion / Fc-gamma receptor signaling pathway / CD28 co-stimulation / FLT3 signaling through SRC family kinases / intracellular zinc ion homeostasis / CD4 receptor binding / Nef Mediated CD4 Down-regulation / Nef and signal transduction / positive regulation of heterotypic cell-cell adhesion / Interleukin-2 signaling / CD28 dependent Vav1 pathway / Regulation of KIT signaling / CTLA4 inhibitory signaling / protein serine/threonine phosphatase activity / phospholipase activator activity / leukocyte migration / CD8 receptor binding / positive regulation of T cell receptor signaling pathway / 中心体マトリックス / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / PECAM1 interactions / CD28 dependent PI3K/Akt signaling / phospholipase binding / RHOH GTPase cycle / 造血 / Generation of second messenger molecules / 免疫シナプス / T cell differentiation / PD-1 signaling / phosphatidylinositol 3-kinase binding / positive regulation of intrinsic apoptotic signaling pathway / T cell receptor binding / peptidyl-tyrosine autophosphorylation / release of sequestered calcium ion into cytosol / extrinsic component of cytoplasmic side of plasma membrane / GPVI-mediated activation cascade / T cell costimulation / phosphotyrosine residue binding / SH2 domain binding / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / cell surface receptor protein tyrosine kinase signaling pathway / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / Signaling by SCF-KIT / 凝固・線溶系 / peptidyl-tyrosine phosphorylation / activation of cysteine-type endopeptidase activity involved in apoptotic process / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of T cell activation / Downstream TCR signaling / PIP3 activates AKT signaling / DAP12 signaling / T cell receptor signaling pathway / ATPase binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / protein phosphatase binding / protein tyrosine kinase activity / intracellular signal transduction / response to xenobiotic stimulus / 脂質ラフト / protein phosphorylation / signaling receptor binding / 自然免疫系 / protein kinase binding / extracellular exosome / ATP binding / identical protein binding / 細胞膜 / 細胞質基質類似検索 - 分子機能 Lck, SH3 domain / Tyrosine-protein kinase Lck, SH2 domain / SH3ドメイン / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily ...Lck, SH3 domain / Tyrosine-protein kinase Lck, SH2 domain / SH3ドメイン / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3ドメイン / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.37 Å |
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データ登録者 | Xu, Z.B. / Moy, F.J. / Kelleher, K. / Mosyak, L. / Protein Structure Factory (PSF) |
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引用 | ジャーナル: J.Med.Chem. / 年: 2010 タイトル: Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance. 著者: Moy, F.J. / Lee, A. / Gavrin, L.K. / Xu, Z.B. / Sievers, A. / Kieras, E. / Stochaj, W. / Mosyak, L. / McKew, J. / Tsao, D.H. |
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履歴 | 登録 | 2009年12月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年6月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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