登録情報 データベース : PDB / ID : 3kek 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound 要素Collagenase 3 詳細 キーワード HYDROLASE/HYDROLASE INHIBITOR / S1' inhibitor / selective MMP-13 inhibitor / S1' specificity / no contact to Zn / Collagen degradation / Disease mutation / Disulfide bond / Extracellular matrix / Glycoprotein / Hydrolase / Metal-binding / Metalloprotease / Protease / Secreted / Zymogen / HYDROLASE-HYDROLASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
growth plate cartilage development / RUNX2 regulates genes involved in cell migration / endochondral ossification / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; その他のペプチターゼ / bone morphogenesis / Assembly of collagen fibrils and other multimeric structures / bone mineralization / Activation of Matrix Metalloproteinases / response to amyloid-beta / Collagen degradation ... growth plate cartilage development / RUNX2 regulates genes involved in cell migration / endochondral ossification / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; その他のペプチターゼ / bone morphogenesis / Assembly of collagen fibrils and other multimeric structures / bone mineralization / Activation of Matrix Metalloproteinases / response to amyloid-beta / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / collagen binding / Degradation of the extracellular matrix / extracellular matrix organization / extracellular matrix / metalloendopeptidase activity / endopeptidase activity / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space / zinc ion binding / extracellular region 類似検索 - 分子機能 Peptidoglycan binding-like / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Putative peptidoglycan binding domain / Hemopexin-like repeats / Hemopexin-like domain superfamily / Hemopexin ... Peptidoglycan binding-like / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Putative peptidoglycan binding domain / Hemopexin-like repeats / Hemopexin-like domain superfamily / Hemopexin / Hemopexin repeat profile. / Hemopexin-like repeats. / Peptidase M10A / Peptidase M10A, catalytic domain / Peptidase M10, metallopeptidase / Matrixin / PGBD-like superfamily / Peptidase, metallopeptidase / Zinc-dependent metalloprotease / Collagenase (Catalytic Domain) / Collagenase (Catalytic Domain) / Metallopeptidase, catalytic domain superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / フーリエ合成 / 解像度 : 1.97 Å 詳細データ登録者 Shieh, H.-S. / Collins, B. / Schnute, M.E. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2009タイトル : Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.著者: Schnute, M.E. / O'Brien, P.M. / Nahra, J. / Morris, M. / Howard Roark, W. / Hanau, C.E. / Ruminski, P.G. / Scholten, J.A. / Fletcher, T.R. / Hamper, B.C. / Carroll, J.N. / Patt, W.C. / Shieh, ... 著者 : Schnute, M.E. / O'Brien, P.M. / Nahra, J. / Morris, M. / Howard Roark, W. / Hanau, C.E. / Ruminski, P.G. / Scholten, J.A. / Fletcher, T.R. / Hamper, B.C. / Carroll, J.N. / Patt, W.C. / Shieh, H.S. / Collins, B. / Pavlovsky, A.G. / Palmquist, K.E. / Aston, K.W. / Hitchcock, J. / Rogers, M.D. / McDonald, J. / Johnson, A.R. / Munie, G.E. / Wittwer, A.J. / Man, C.F. / Settle, S.L. / Nemirovskiy, O. / Vickery, L.E. / Agawal, A. / Dyer, R.D. / Sunyer, T. 履歴 登録 2009年10月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2010年11月10日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2017年11月1日 Group : Refinement description / カテゴリ : software改定 1.3 2024年2月21日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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