Entry Database : PDB / ID : 3jyu Structure visualization Downloads & linksTitle Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4) ComponentsUbiquitin carboxyl-terminal hydrolase Details Keywords HYDROLASE / Domain in ubiquitin-specific peptidases (DUSP) / proto-oncogene / Ubiquitin-fold / Ubl / protease / thioesterase / Thiol protease / Ubl conjugation pathway / Structural Genomics / Structural Genomics Consortium / SGCFunction / homology Function and homology informationFunction Domain/homology Component
adenosine receptor binding / TNFR1-induced proapoptotic signaling / TNFR1-induced NF-kappa-B signaling pathway / Regulation of TNFR1 signaling / Ub-specific processing proteases / protein localization to cell surface / protein deubiquitination / spliceosomal tri-snRNP complex assembly / negative regulation of protein ubiquitination / regulation of protein stability ... adenosine receptor binding / TNFR1-induced proapoptotic signaling / TNFR1-induced NF-kappa-B signaling pathway / Regulation of TNFR1 signaling / Ub-specific processing proteases / protein localization to cell surface / protein deubiquitination / spliceosomal tri-snRNP complex assembly / negative regulation of protein ubiquitination / regulation of protein stability / ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / identical protein binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function DUSP-like / DUSP-like / Ubiquitin-like domain, USP-type / Ubiquitin-like domain / Peptidase C19, ubiquitin-specific peptidase, DUSP domain / DUSP-like superfamily / DUSP domain / DUSP domain profile. / Domain in ubiquitin-specific proteases. / Ubiquitin specific protease (USP) domain signature 2. ... DUSP-like / DUSP-like / Ubiquitin-like domain, USP-type / Ubiquitin-like domain / Peptidase C19, ubiquitin-specific peptidase, DUSP domain / DUSP-like superfamily / DUSP domain / DUSP domain profile. / Domain in ubiquitin-specific proteases. / Ubiquitin specific protease (USP) domain signature 2. / Ubiquitin specific protease (USP) domain signature 1. / Ubiquitin specific protease, conserved site / Peptidase C19, ubiquitin carboxyl-terminal hydrolase / Ubiquitin carboxyl-terminal hydrolase / Ubiquitin specific protease domain / Ubiquitin specific protease (USP) domain profile. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Papain-like cysteine peptidase superfamily / Ubiquitin-like (UB roll) / Roll / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE / Ubiquitin carboxyl-terminal hydrolase 4 / Ubiquitin carboxyl-terminal hydrolase Similarity search - ComponentBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / molecular replacementSAD / Resolution : 2.37 Å DetailsAuthors Bacik, J.P. / Avvakumov, G. / Walker, J.R. / Xue, S. / Arrowsmith, C.H. / Edwards, A.M. / Bochkarev, A. / Dhe-Paganon, S. / Structural Genomics Consortium (SGC) CitationJournal : To be Published Title : Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)Authors : Bacik, J.P. / Avvakumov, G. / Walker, J.R. / Xue, S. / Dhe-Paganon, S. History Deposition Sep 22, 2009 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 20, 2009 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Nov 1, 2017 Group : Refinement description / Category : softwareRevision 1.3 Sep 6, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Nov 22, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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