登録情報 | データベース: PDB / ID: 3iar |
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タイトル | The crystal structure of human adenosine deaminase |
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要素 | Adenosine deaminase |
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キーワード | HYDROLASE / deaminase / adenosine deaminase / adenosine / purine metabolism / Structural Genomics / Structural Genomics Consortium / SGC / Disease mutation / Hereditary hemolytic anemia / Nucleotide metabolism / SCID |
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機能・相同性 | 機能・相同性情報
purine nucleotide salvage / Defective ADA disrupts (deoxy)adenosine deamination / mature B cell apoptotic process / xanthine biosynthetic process / negative regulation of penile erection / negative regulation of mucus secretion / penile erection / positive regulation of germinal center formation / negative regulation of adenosine receptor signaling pathway / cytoplasmic vesicle lumen ...purine nucleotide salvage / Defective ADA disrupts (deoxy)adenosine deamination / mature B cell apoptotic process / xanthine biosynthetic process / negative regulation of penile erection / negative regulation of mucus secretion / penile erection / positive regulation of germinal center formation / negative regulation of adenosine receptor signaling pathway / cytoplasmic vesicle lumen / inosine biosynthetic process / 2'-deoxyadenosine deaminase activity / amide catabolic process / adenosine deaminase / germinal center B cell differentiation / purine-containing compound salvage / adenosine catabolic process / adenosine deaminase activity / deaminase activity / hypoxanthine salvage / deoxyadenosine catabolic process / dAMP catabolic process / AMP catabolic process / adenosine metabolic process / positive regulation of T cell differentiation in thymus / dATP catabolic process / mucus secretion / Ribavirin ADME / negative regulation of leukocyte migration / regulation of cell-cell adhesion mediated by integrin / allantoin metabolic process / embryonic digestive tract development / trophectodermal cell differentiation / response to purine-containing compound / GMP salvage / Purine salvage / positive regulation of smooth muscle contraction / Peyer's patch development / germinal center formation / negative regulation of mature B cell apoptotic process / AMP salvage / negative regulation of thymocyte apoptotic process / anchoring junction / positive regulation of alpha-beta T cell differentiation / alpha-beta T cell differentiation / positive regulation of heart rate / leukocyte migration / lung alveolus development / positive regulation of T cell receptor signaling pathway / thymocyte apoptotic process / B cell proliferation / smooth muscle contraction / : / positive regulation of B cell proliferation / T cell activation / positive regulation of calcium-mediated signaling / xenobiotic metabolic process / liver development / placenta development / calcium-mediated signaling / negative regulation of inflammatory response / T cell receptor signaling pathway / T cell differentiation in thymus / lysosome / response to hypoxia / cell adhesion / external side of plasma membrane / cell surface / zinc ion binding / membrane / plasma membrane / cytosol類似検索 - 分子機能 Adenosine deaminase / Adenosine/AMP deaminase active site / Adenosine and AMP deaminase signature. / Adenosine deaminase domain / Adenosine deaminase / Adenosine/adenine deaminase / Metal-dependent hydrolases / Metal-dependent hydrolase / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-3D1 / NICKEL (II) ION / NITRATE ION / Adenosine deaminase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.52 Å |
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データ登録者 | Ugochukwu, E. / Zhang, Y. / Hapka, E. / Yue, W.W. / Bray, J.E. / Muniz, J. / Burgess-Brown, N. / Chaikuad, A. / von Delft, F. / Bountra, C. ...Ugochukwu, E. / Zhang, Y. / Hapka, E. / Yue, W.W. / Bray, J.E. / Muniz, J. / Burgess-Brown, N. / Chaikuad, A. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Kavanagh, K.L. / Oppermann, U. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: To be Published タイトル: The crystal structure of human adenosine deaminase 著者: Ugochukwu, E. / Zhang, Y. / Hapka, E. / Yue, W.W. / Bray, J.E. / Muniz, J. / Burgess-Brown, N. / Chaikuad, A. / Kavanagh, K.L. / Oppermann, U. |
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履歴 | 登録 | 2009年7月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年8月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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