Entry Database : PDB / ID : 3hs9 Structure visualization Downloads & linksTitle Intersectin 1-peptide-AP2 beta ear complex ComponentsAP-2 complex subunit beta-1 peptide from Intersectin-1, residues 841-851 DetailsKeywords ENDOCYTOSIS / clathrin / adaptor complex AP-2 / Alternative splicing / Cell membrane / Coated pit / Membrane / Disease mutation / TransferaseFunction / homology Function and homology informationFunction Domain/homology Component
: / AP-type membrane coat adaptor complex / NRAGE signals death through JNK / presynaptic endocytic zone / RHOQ GTPase cycle / G alpha (12/13) signalling events / positive regulation of caveolin-mediated endocytosis / clathrin-dependent synaptic vesicle endocytosis / CDC42 GTPase cycle / protein localization => GO:0008104 ... : / AP-type membrane coat adaptor complex / NRAGE signals death through JNK / presynaptic endocytic zone / RHOQ GTPase cycle / G alpha (12/13) signalling events / positive regulation of caveolin-mediated endocytosis / clathrin-dependent synaptic vesicle endocytosis / CDC42 GTPase cycle / protein localization => GO:0008104 / EPHB-mediated forward signaling / NRAGE signals death through JNK / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / LDL clearance / VLDLR internalisation and degradation / Retrograde neurotrophin signalling / clathrin adaptor complex / RHOG GTPase cycle / WNT5A-dependent internalization of FZD4 / clathrin coat / extrinsic component of presynaptic endocytic zone membrane / cardiac septum development / G alpha (12/13) signalling events / MHC class II antigen presentation / AP-2 adaptor complex / positive regulation of growth hormone secretion / postsynaptic neurotransmitter receptor internalization / Recycling pathway of L1 / postsynaptic actin cytoskeleton / clathrin coat assembly / Cargo recognition for clathrin-mediated endocytosis / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / Clathrin-mediated endocytosis / regulation of modification of postsynaptic actin cytoskeleton / EPHB-mediated forward signaling / clathrin-dependent endocytosis / apical dendrite / coronary vasculature development / positive regulation of protein localization to membrane / neurotransmitter receptor internalization / kinase activator activity / proline-rich region binding / aorta development / ventricular septum development / regulation of postsynapse organization / endosomal transport / clathrin binding / small GTPase-mediated signal transduction / intracellular vesicle / positive regulation of dendritic spine development / exocytosis / positive regulation of endocytosis / Trafficking of GluR2-containing AMPA receptors / calyx of Held / synaptic vesicle endocytosis / endocytic vesicle / clathrin-coated pit / vesicle-mediated transport / guanyl-nucleotide exchange factor activity / kidney development / intracellular protein transport / brain development / terminal bouton / recycling endosome / endocytosis / protein transport / lamellipodium / nuclear envelope / presynaptic membrane / heart development / neuron apoptotic process / postsynapse / negative regulation of neuron apoptotic process / dendritic spine / molecular adaptor activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / neuronal cell body / glutamatergic synapse / synapse / calcium ion binding / protein-containing complex binding / plasma membrane / cytosol / cytoplasm Similarity search - Function Immunoglobulin-like - #1150 / Intersectin-1, AP2 binding region / Intersectin and clathrin adaptor AP2 binding region / : / Pleckstrin homology domain / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / TATA-Binding Protein ... Immunoglobulin-like - #1150 / Intersectin-1, AP2 binding region / Intersectin and clathrin adaptor AP2 binding region / : / Pleckstrin homology domain / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / TATA-Binding Protein / Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain / Beta-adaptin appendage, C-terminal subdomain / AP-1/2/4 complex subunit beta / Beta2-adaptin appendage, C-terminal sub-domain / Beta2-adaptin appendage, C-terminal sub-domain / AP complex subunit beta / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Coatomer/calthrin adaptor appendage, C-terminal subdomain / Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain / Adaptin C-terminal domain / Adaptin C-terminal domain / Clathrin/coatomer adaptor, adaptin-like, N-terminal / Adaptin N terminal region / Clathrin adaptor, appendage, Ig-like subdomain superfamily / TATA-Binding Protein / Variant SH3 domain / Variant SH3 domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / TBP domain superfamily / C2 domain / Protein kinase C conserved region 2 (CalB) / Armadillo/beta-catenin-like repeats / Armadillo / C2 domain / C2 domain profile. / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / Src homology 3 domains / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / EF-hand domain / Src homology 3 (SH3) domain profile. / SH3 domain / Armadillo-like helical / EF-hand domain pair / PH-like domain superfamily / Armadillo-type fold / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.15 Å DetailsAuthors Vahedi-Faridi, A. / Pechstein, A. / Schaefer, J.G. / Saenger, W. / Haucke, V. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2010Title : Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.Authors : Pechstein, A. / Bacetic, J. / Vahedi-Faridi, A. / Gromova, K. / Sundborger, A. / Tomlin, N. / Krainer, G. / Vorontsova, O. / Schafer, J.G. / Owe, S.G. / Cousin, M.A. / Saenger, W. / Shupliakov, O. / Haucke, V. History Deposition Jun 10, 2009 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Feb 23, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Nov 1, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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