登録情報 データベース : PDB / ID : 3fx0 構造の表示 ダウンロードとリンクタイトル Crystal structure of Human NEMO CC2_LZ domain 要素NF-kappa-B essential modulator 詳細 キーワード SIGNALING PROTEIN / Coiled-coil / Coiled coil / Cytoplasm / Disease mutation / Ectodermal dysplasia / Host-virus interaction / Metal-binding / Nucleus / Osteopetrosis / Phosphoprotein / Transcription / Transcription regulation / Ubl conjugation / Zinc / Zinc-finger機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / SLC15A4:TASL-dependent IRF5 activation / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / SUMOylation of immune response proteins ... IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / SLC15A4:TASL-dependent IRF5 activation / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / SUMOylation of immune response proteins / RIP-mediated NFkB activation via ZBP1 / positive regulation of ubiquitin-dependent protein catabolic process / anoikis / Modulation of host responses by IFN-stimulated genes / K63-linked polyubiquitin modification-dependent protein binding / positive regulation of T cell receptor signaling pathway / TRAF6 mediated NF-kB activation / B cell homeostasis / positive regulation of macroautophagy / polyubiquitin modification-dependent protein binding / canonical NF-kappaB signal transduction / ubiquitin ligase complex / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / MAP3K8 (TPL2)-dependent MAPK1/3 activation / TICAM1, RIP1-mediated IKK complex recruitment / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / signaling adaptor activity / IKK complex recruitment mediated by RIP1 / TNFR1-induced NF-kappa-B signaling pathway / activated TAK1 mediates p38 MAPK activation / Regulation of NF-kappa B signaling / Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells / Regulation of TNFR1 signaling / Activation of NF-kappaB in B cells / NOD1/2 Signaling Pathway / TAK1-dependent IKK and NF-kappa-B activation / CLEC7A (Dectin-1) signaling / positive regulation of NF-kappaB transcription factor activity / FCERI mediated NF-kB activation / PKR-mediated signaling / Interleukin-1 signaling / response to virus / Ovarian tumor domain proteases / spindle pole / mitotic spindle / Downstream TCR signaling / ER-Phagosome pathway / T cell receptor signaling pathway / protein-containing complex assembly / positive regulation of canonical NF-kappaB signal transduction / Ub-specific processing proteases / defense response to bacterium / immune response / inflammatory response / protein heterodimerization activity / protein domain specific binding / innate immune response / ubiquitin protein ligase binding / apoptotic process / DNA damage response / positive regulation of gene expression / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Nemo cc2-lz domain - 1d5 darpin complex / NF-kappa-B essential modulator NEMO, N-terminal / : / NF-kappa-B essential modulator NEMO / C2H2 type zinc-finger / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator / Single alpha-helices involved in coiled-coils or other helix-helix interfaces ... Nemo cc2-lz domain - 1d5 darpin complex / NF-kappa-B essential modulator NEMO, N-terminal / : / NF-kappa-B essential modulator NEMO / C2H2 type zinc-finger / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 単波長異常分散 / 解像度 : 3.2 Å 詳細データ登録者 Lo, Y.C. / Lin, S.C. / Wu, H. 引用ジャーナル : Mol.Cell / 年 : 2009タイトル : Structural basis for recognition of diubiquitins by NEMO.著者 : Lo, Y.C. / Lin, S.C. / Rospigliosi, C.C. / Conze, D.B. / Wu, C.J. / Ashwell, J.D. / Eliezer, D. / Wu, H. 履歴 登録 2009年1月19日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2009年4月7日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2017年11月1日 Group : Refinement description / カテゴリ : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version 改定 1.3 2024年2月21日 Group : Data collection / Database referencesカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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