- PDB-3fck: Complex of UNG2 and a fragment-based design inhibitor -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 3fck
Title
Complex of UNG2 and a fragment-based design inhibitor
Components
Uracil-DNA glycosylase
Keywords
HYDROLASE / DNA REPAIR / URACIL / URACIL DNA GLYCOSYLASE / Alternative splicing / Disease mutation / DNA damage / Glycosidase / Host-virus interaction / Mitochondrion / Nucleus / Phosphoprotein / Transit peptide
Function / homology
Function and homology information
base-excision repair, AP site formation via deaminated base removal / uracil-DNA glycosylase / depyrimidination / Displacement of DNA glycosylase by APEX1 / isotype switching / uracil DNA N-glycosylase activity / ribosomal small subunit binding / somatic hypermutation of immunoglobulin genes / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine ...base-excision repair, AP site formation via deaminated base removal / uracil-DNA glycosylase / depyrimidination / Displacement of DNA glycosylase by APEX1 / isotype switching / uracil DNA N-glycosylase activity / ribosomal small subunit binding / somatic hypermutation of immunoglobulin genes / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Chromatin modifications during the maternal to zygotic transition (MZT) / base-excision repair / damaged DNA binding / negative regulation of apoptotic process / mitochondrion / nucleoplasm / nucleus Similarity search - Function
Uracil-DNA glycosylase family 1 / UreE urease accessory protein, C-terminal domain / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase, active site / Uracil-DNA glycosylase signature. / Uracil-DNA Glycosylase, subunit E / Uracil-DNA glycosylase-like domain / Uracil-DNA glycosylase-like / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase-like domain superfamily ...Uracil-DNA glycosylase family 1 / UreE urease accessory protein, C-terminal domain / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase, active site / Uracil-DNA glycosylase signature. / Uracil-DNA Glycosylase, subunit E / Uracil-DNA glycosylase-like domain / Uracil-DNA glycosylase-like / Uracil DNA glycosylase superfamily / Uracil-DNA glycosylase-like domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 210 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.05 Å3/Da / Density % sol: 39.9 %
Crystal grow
Temperature: 295 K / Method: vapor diffusion, hanging drop / pH: 8 Details: 1 MICROLITER OF THE SOLUTION: 0.001 M UNG2 0.05 M TRIS-OAC pH 7.0, 0.15 M NACL 0.001 M DTT 0.005 M INHIBITOR, WAS MIXED WITH EQUAL AMOUNT OF THE SOLUTION CONTAINING 0.16 M KSCN AND 22% PEG ...Details: 1 MICROLITER OF THE SOLUTION: 0.001 M UNG2 0.05 M TRIS-OAC pH 7.0, 0.15 M NACL 0.001 M DTT 0.005 M INHIBITOR, WAS MIXED WITH EQUAL AMOUNT OF THE SOLUTION CONTAINING 0.16 M KSCN AND 22% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 295K
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