登録情報 | データベース: PDB / ID: 3dgr |
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タイトル | Crystal structure of human NAMPT complexed with ADP analogue |
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要素 | Nicotinamide phosphoribosyltransferase |
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キーワード | TRANSFERASE / NMPRTase / Visfatin / Adenosine 5'-(alpha / beta-methylene)diphosphate / Alternative splicing / Cytoplasm / Glycosyltransferase / Phosphoprotein / Polymorphism / Pyridine nucleotide biosynthesis |
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機能・相同性 | 機能・相同性情報
nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / NAD biosynthesis via nicotinamide riboside salvage pathway / Nicotinamide salvaging / NAD biosynthetic process / positive regulation of nitric-oxide synthase biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian gene expression / cytokine activity / circadian regulation of gene expression ...nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / NAD biosynthesis via nicotinamide riboside salvage pathway / Nicotinamide salvaging / NAD biosynthetic process / positive regulation of nitric-oxide synthase biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian gene expression / cytokine activity / circadian regulation of gene expression / cell junction / cell-cell signaling / nuclear speck / positive regulation of cell population proliferation / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular exosome / identical protein binding / cytosol類似検索 - 分子機能 Nicotinamide phosphoribosyl transferase / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinate/nicotinamide phosphoribosyltransferase / Nicotinate phosphoribosyltransferase (NAPRTase) family / Nicotinate phosphoribosyltransferase-like, C-terminal / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER / Nicotinamide phosphoribosyltransferase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Ho, M. / Burgos, E.S. / Almo, S.C. / Schramm, V.L. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2009 タイトル: A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. 著者: Burgos, E.S. / Ho, M.C. / Almo, S.C. / Schramm, V.L. |
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履歴 | 登録 | 2008年6月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年8月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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