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- PDB-3ckx: Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in co... -
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Open data
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Basic information
Entry | Database: PDB / ID: 3ckx | ||||||
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Title | Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine | ||||||
![]() | Serine/threonine-protein kinase 24![]() | ||||||
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Function / homology | ![]() Apoptotic execution phase / regulation of axon regeneration / execution phase of apoptosis / intrinsic apoptotic signaling pathway in response to oxidative stress / positive regulation of axon regeneration / Apoptotic cleavage of cellular proteins / cellular response to starvation / negative regulation of cell migration / response to hydrogen peroxide / protein autophosphorylation ...Apoptotic execution phase / regulation of axon regeneration / execution phase of apoptosis / intrinsic apoptotic signaling pathway in response to oxidative stress / positive regulation of axon regeneration / Apoptotic cleavage of cellular proteins / cellular response to starvation / negative regulation of cell migration / response to hydrogen peroxide / protein autophosphorylation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Antonysamy, S.S. / Burley, S.K. / Buchanan, S. / Chau, F. / Feil, I. / Wu, L. / Sauder, J.M. / New York SGX Research Center for Structural Genomics (NYSGXRC) | ||||||
![]() | ![]() Title: Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine. Authors: Antonysamy, S.S. / Burley, S.K. / Buchanan, S. / Chau, F. / Feil, I. / Wu, L. / Sauder, J.M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 69.8 KB | Display | ![]() |
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PDB format | ![]() | 50 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 3ckwS S: Starting model for refinement |
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Similar structure data | |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 34653.211 Da / Num. of mol.: 1 / Fragment: Residues 31-323 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: Q9Y6E0, ![]() |
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#2: Chemical | ChemComp-STU / ![]() |
#3: Water | ChemComp-HOH / ![]() |
Sequence details | THE TARGETDB ID NYSGXRC-5632A PROVIDED BY AUTHORS FOR THIS PROTEIN DID NOT EXIST IN TARGET DATABASE ...THE TARGETDB ID NYSGXRC-5632A PROVIDED BY AUTHORS FOR THIS PROTEIN DID NOT EXIST IN TARGET DATABASE AT THE TIME OF DEPOSITION |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.08 Å3/Da / Density % sol: 40.84 % |
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Crystal grow![]() | Temperature: 292 K / Method: vapor diffusion / pH: 8.5 Details: 22% PEG 4000, 100 mM Tris-HCl, 200 mM Sodium acetate, pH 8.5, VAPOR DIFFUSION, temperature 292K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: MAR CCD 165 mm / Detector: CCD / Date: Jan 9, 2001 |
Radiation | Monochromator: DIAMOND / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.7→50 Å / Num. obs: 7930 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: PDB entry 3CKW Resolution: 2.7→24.77 Å
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Displacement parameters | Biso mean: 56.855 Å2 | ||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.7→24.77 Å
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