Entry Database : PDB / ID : 3bxl Structure visualization Downloads & linksTitle Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex ComponentsCalmodulin Voltage-dependent R-type calcium channel subunit alpha-1E peptide DetailsKeywords MEMBRANE PROTEIN / SIGNALING PROTEIN / ION CHANNEL / CALMODULIN / CALCIUM CHANNEL / IQ DOMAIN / FACILLITATION / INACTIVATION / CALCIUM-DEPENDENT / VOLTAGE-GATED / ROBETTA / SIMULATIONS / Acetylation / Methylation / Phosphoprotein / Ubl conjugation / Calcium transport / Glycoprotein / Ion transport / Ionic channel / Membrane / Transmembrane / Transport / Voltage-gated channelFunction / homology Function and homology informationFunction Domain/homology Component
regulation of somatostatin secretion / low voltage-gated calcium channel activity / voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / regulation of store-operated calcium channel activity / Presynaptic depolarization and calcium channel opening / Regulation of insulin secretion / regulation of high voltage-gated calcium channel activity / Presynaptic depolarization and calcium channel opening / : / flagellated sperm motility ... regulation of somatostatin secretion / low voltage-gated calcium channel activity / voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / regulation of store-operated calcium channel activity / Presynaptic depolarization and calcium channel opening / Regulation of insulin secretion / regulation of high voltage-gated calcium channel activity / Presynaptic depolarization and calcium channel opening / : / flagellated sperm motility / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / high voltage-gated calcium channel activity / : / regulation of insulin secretion involved in cellular response to glucose stimulus / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / fear response / voltage-gated monoatomic cation channel activity / calcium ion import / establishment of protein localization to membrane / nervous system process / regulation of synaptic vesicle endocytosis / voltage-gated calcium channel complex / negative regulation of high voltage-gated calcium channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / response to pain / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / transmission of nerve impulse / behavioral response to pain / protein phosphatase activator activity / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / detection of calcium ion / calcium channel regulator activity / regulation of cardiac muscle contraction / calcium ion import across plasma membrane / negative regulation of ryanodine-sensitive calcium-release channel activity / GABA-ergic synapse / voltage-gated calcium channel activity / behavioral fear response / calcium channel inhibitor activity / cellular response to interferon-beta / positive regulation of DNA binding / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / enzyme regulator activity / regulation of calcium-mediated signaling / positive regulation of protein dephosphorylation / potassium ion transmembrane transport / titin binding / regulation of ryanodine-sensitive calcium-release channel activity / voltage-gated potassium channel complex / sensory perception of pain / sperm midpiece / calcium channel complex / response to amphetamine / activation of adenylate cyclase activity / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / positive regulation of nitric-oxide synthase activity / locomotory behavior / Regulation of insulin secretion / establishment of localization in cell / calcium-mediated signaling / calcium ion transmembrane transport / positive regulation of receptor signaling pathway via JAK-STAT / visual learning / spindle microtubule / cellular response to type II interferon / spindle pole / response to calcium ion / G2/M transition of mitotic cell cycle / calcium ion transport / calcium-dependent protein binding / disordered domain specific binding / myelin sheath / glucose homeostasis / presynaptic membrane / growth cone / chemical synaptic transmission / postsynaptic membrane / perikaryon / vesicle / transmembrane transporter binding / protein autophosphorylation / neuron projection Similarity search - Function Voltage-dependent calcium channel, R-type, alpha-1 subunit / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain / Voltage gated calcium channel IQ domain / Voltage-dependent calcium channel, alpha-1 subunit / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage-dependent channel domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif ... Voltage-dependent calcium channel, R-type, alpha-1 subunit / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain / Voltage gated calcium channel IQ domain / Voltage-dependent calcium channel, alpha-1 subunit / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage-dependent channel domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Ion transport domain / Ion transport protein / EF-hand domain pair Similarity search - Domain/homology Calmodulin-1 / Calmodulin-1 / Voltage-dependent R-type calcium channel subunit alpha-1E / Voltage-dependent R-type calcium channel subunit alpha-1E Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Mori, M.X. / Vander Kooi, C.W. / Leahy, D.J. / Yue, D.T. CitationJournal : To be Published Title : Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulinAuthors : Mori, M.X. / Vander Kooi, C.W. / Leahy, D.J. / Yue, D.T. History Deposition Jan 14, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 25, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Feb 21, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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