登録情報 | データベース: PDB / ID: 3aqf |
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タイトル | Crystal structure of the human CRLR/RAMP2 extracellular complex |
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要素 | - Calcitonin gene-related peptide type 1 receptor
- Receptor activity-modifying protein 2
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キーワード | TRANSPORT PROTEIN/MEMBRANE PROTEIN / Transmembrane / GPCR / Adrenomedullin / TRAFFICKING / CLR / CGRP / Endoplasmic Reticulum / AM-receptor / DISEASE / Neovascularization / Co-activating receptor for Adrenomedullin / Adrenomedullin (AM) / Endoplasmic Reticulum (ER) / TRANSPORT PROTEIN-MEMBRANE PROTEIN complex |
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機能・相同性 | 機能・相同性情報
vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / basement membrane assembly / cellular response to sucrose stimulus / adrenomedullin receptor activity / adrenomedullin receptor complex / adrenomedullin receptor signaling pathway / calcitonin receptor activity ...vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / basement membrane assembly / cellular response to sucrose stimulus / adrenomedullin receptor activity / adrenomedullin receptor complex / adrenomedullin receptor signaling pathway / calcitonin receptor activity / vascular associated smooth muscle cell proliferation / calcitonin gene-related peptide receptor activity / Calcitonin-like ligand receptors / positive regulation of vasculogenesis / bicellular tight junction assembly / regulation of G protein-coupled receptor signaling pathway / adherens junction assembly / negative regulation of vascular permeability / sprouting angiogenesis / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / cellular response to vascular endothelial growth factor stimulus / vasculogenesis / coreceptor activity / negative regulation of endothelial cell apoptotic process / clathrin-coated pit / cellular response to hormone stimulus / positive regulation of vascular associated smooth muscle cell proliferation / protein localization to plasma membrane / G protein-coupled receptor activity / intracellular protein transport / adenylate cyclase-activating G protein-coupled receptor signaling pathway / receptor internalization / regulation of blood pressure / positive regulation of angiogenesis / calcium ion transport / protein transport / heart development / G alpha (s) signalling events / angiogenesis / cell surface receptor signaling pathway / lysosome / receptor complex / endosome / G protein-coupled receptor signaling pathway / positive regulation of gene expression / cell surface / endoplasmic reticulum / plasma membrane / cytoplasm類似検索 - 分子機能 Receptor activity modifying family / GPCR, family 2, calcitonin gene-related peptide, type 1 receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Receptor activity modifying protein / RAMP domain superfamily / Receptor activity modifying family / GPCR, family 2, calcitonin receptor family / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ...Receptor activity modifying family / GPCR, family 2, calcitonin gene-related peptide, type 1 receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Receptor activity modifying protein / RAMP domain superfamily / Receptor activity modifying family / GPCR, family 2, calcitonin receptor family / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / DNA polymerase; domain 1 / Few Secondary Structures / Irregular / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Receptor activity-modifying protein 2 / Calcitonin gene-related peptide type 1 receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 2.6 Å |
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データ登録者 | Kusano, S. / Kukimono-Niino, M. / Shirouzu, M. / Shindo, T. / Yokoyama, S. |
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引用 | ジャーナル: Protein Sci. / 年: 2012 タイトル: Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding 著者: Kusano, S. / Kukimoto-Niino, M. / Hino, N. / Ohsawa, N. / Okuda, K. / Sakamoto, K. / Shirouzu, M. / Shindo, T. / Yokoyama, S. |
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履歴 | 登録 | 2010年10月29日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2011年11月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年7月25日 | Group: Database references |
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