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- PDB-35uh: Crystal structure of TFPI K2 domain in complex with TFPI-23 Fab f... -

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Basic information

Entry
Database: PDB / ID: 35uh
TitleCrystal structure of TFPI K2 domain in complex with TFPI-23 Fab fragment
Components
  • TFPI-23-Fab Heavy chain
  • TFPI-23-Fab Light chain
  • Tissue factor pathway inhibitor
KeywordsBLOOD CLOTTING / Tissue factor pathway inhibitor / antibody / Fab fragment / TFPI / Kunitz domain / Factor Xa
Function / homology
Function and homology information


serine-type endopeptidase inhibitor activity / blood coagulation / :
Similarity search - Function
Tissue factor pathway inhibitor-like / : / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily
Similarity search - Domain/homology
Tissue factor pathway inhibitor
Similarity search - Component
Biological speciesHomo sapiens (human)
Macaca fascicularis (crab-eating macaque)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.11 Å
AuthorsJuo, Z.S. / Bard, J. / Mosyak, L.
Funding support1items
OrganizationGrant numberCountry
Not funded
CitationJournal: To Be Published
Title: Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B
Authors: Jin, M. / Hett, S. / Jasuja, R. / Rakhe, S. / Narula, J. / Tam, A. / Apgar, J.R. / Juo, Z.S. / Mosyak, L. / Holsti, M. / Joyce, A. / Hurst, S. / Webster, R. / Lin, L. / Stahl, M. / Pittman, D.D. / Bloom, L.
History
DepositionMay 18, 2026Deposition site: RCSB / Processing site: RCSB
Revision 1.0May 27, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: TFPI-23-Fab Heavy chain
B: TFPI-23-Fab Light chain
C: Tissue factor pathway inhibitor
D: TFPI-23-Fab Heavy chain
E: TFPI-23-Fab Light chain
F: Tissue factor pathway inhibitor
G: TFPI-23-Fab Heavy chain
H: TFPI-23-Fab Light chain
I: Tissue factor pathway inhibitor
J: TFPI-23-Fab Heavy chain
K: TFPI-23-Fab Light chain
L: Tissue factor pathway inhibitor
M: TFPI-23-Fab Heavy chain
N: TFPI-23-Fab Light chain
O: Tissue factor pathway inhibitor
P: TFPI-23-Fab Heavy chain
Q: TFPI-23-Fab Light chain
R: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)323,83718
Polymers323,83718
Non-polymers00
Water00
1
A: TFPI-23-Fab Heavy chain
B: TFPI-23-Fab Light chain
C: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
D: TFPI-23-Fab Heavy chain
E: TFPI-23-Fab Light chain
F: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
G: TFPI-23-Fab Heavy chain
H: TFPI-23-Fab Light chain
I: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
J: TFPI-23-Fab Heavy chain
K: TFPI-23-Fab Light chain
L: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
M: TFPI-23-Fab Heavy chain
N: TFPI-23-Fab Light chain
O: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
6
P: TFPI-23-Fab Heavy chain
Q: TFPI-23-Fab Light chain
R: Tissue factor pathway inhibitor


Theoretical massNumber of molelcules
Total (without water)53,9733
Polymers53,9733
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)74.669, 101.372, 119.275
Angle α, β, γ (deg.)101.830, 92.272, 96.776
Int Tables number1
Space group name H-MP1
Space group name HallP1
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails (eV)
d_1ens_1(chain "A" and (resid 1 through 133 or resid 142 through 220))
d_2ens_1chain "D"
d_3ens_1chain "G"
d_4ens_1chain "J"
d_1ens_2(chain "B" and (resid 1 through 155 or resid 158 through 214))
d_2ens_2(chain "E" and (resid 1 through 155 or resid 158 through 214))
d_3ens_2chain "H"
d_4ens_2chain "K"
d_1ens_3chain "C"
d_2ens_3chain "F"
d_3ens_3chain "I"
d_4ens_3chain "L"
d_5ens_3chain "O"
d_6ens_3chain "R"
d_1ens_4chain "M"
d_2ens_4chain "P"
d_1ens_5chain "N"
d_2ens_5chain "Q"

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
d_11ens_1GLNGLNPROPROAA1 - 1331 - 133
d_12ens_1THRTHRPROPROAA142 - 220142 - 220
d_21ens_1GLNGLNPROPRODD1 - 2201 - 220
d_31ens_1GLNGLNPROPROGG1 - 2201 - 220
d_41ens_1GLNGLNPROPROJJ1 - 2201 - 220
d_11ens_2GLNGLNLYSLYSBB1 - 1551 - 155
d_12ens_2SERSERPROPROBB158 - 214158 - 214
d_21ens_2GLNGLNLYSLYSEE1 - 1551 - 155
d_22ens_2SERSERPROPROEE158 - 214158 - 214
d_31ens_2GLNGLNPROPROHH1 - 2141 - 214
d_41ens_2GLNGLNPROPROKK1 - 2141 - 214
d_11ens_3LYSLYSGLUGLUCC93 - 1486 - 61
d_21ens_3LYSLYSGLUGLUFF93 - 1486 - 61
d_31ens_3LYSLYSGLUGLUII93 - 1486 - 61
d_41ens_3LYSLYSGLUGLULL93 - 1486 - 61
d_51ens_3LYSLYSGLUGLUOO93 - 1486 - 61
d_61ens_3LYSLYSGLUGLURR93 - 1486 - 61
d_11ens_4GLNGLNSERSERMM1 - 1201 - 120
d_21ens_4GLNGLNSERSERPP1 - 1201 - 120
d_11ens_5GLNGLNGLYGLYNN1 - 1131 - 113
d_21ens_5GLNGLNGLYGLYQQ1 - 1131 - 113

NCS ensembles :
ID
ens_1
ens_2
ens_3
ens_4
ens_5

NCS oper:
IDCodeMatrixVector
1given(0.9908641037103, -0.12524436982516, -0.050021753322829), (-0.097212693946201, -0.92037114495478, 0.37876991389279), (-0.09347737755261, -0.37044676184538, -0.92413807221873)-32.274598452813, -16.149269542889, 12.204753138633
2given(-0.92983627691233, 0.038907391750362, 0.3659107992462), (-0.20801370270264, 0.76468731590556, -0.60990458957208), (-0.30353714373326, -0.64322587304953, -0.70294073620322)-68.690382326765, -9.2124780929438, 51.036100196062
3given(0.98916556266995, 0.032732334595925, -0.14310864369331), (-0.14570889784437, 0.33776552981891, -0.92988352171395), (0.01789990829076, 0.94066095971825, 0.33887542275168)17.204925985213, -0.71169495142329, 9.0766929985417
4given(0.9911480154806, -0.12372769086971, -0.04813595247753), (-0.092240214964218, -0.9025444426497, 0.42060108390908), (-0.095484837289612, -0.41243785902144, -0.90596780201814)-32.420527311672, -16.505395142063, 9.9669840741487
5given(-0.91132071856124, 0.10978723438804, 0.39678874868935), (-0.24169789458176, 0.63754387594917, -0.73151892251291), (-0.33328167617764, -0.76255135525756, -0.55447159974077)-64.810771090766, -11.060570776123, 41.939266285473
6given(0.98914235403358, 0.049807894607654, -0.13826271041629), (-0.14673603308907, 0.38671314672079, -0.91045125006591), (0.0081203479105395, 0.92085401437364, 0.38982296515438)18.927791689241, -0.22156239629611, 6.3975388963429
7given(0.99793378291246, -0.036601489561682, -0.052806210656476), (-0.0063949792526525, -0.87437780957649, 0.48520361742322), (-0.06393175394425, -0.4838633867964, -0.87280522097174)-29.540166306131, -13.1941979637, 9.9470771453894
8given(-0.81270813584408, -0.069467093333079, 0.57851517601243), (-0.4742315254713, 0.65573164743982, -0.58746954541918), (-0.33854090769359, -0.75179141355147, -0.56586193044619)-71.765257035577, -23.658292140709, 42.359721283918
9given(0.99849528261033, 0.035721577376599, -0.041606964737187), (-0.050346226851954, 0.29642350402013, -0.95372866356538), (-0.021735409972792, 0.95438832514557, 0.29777591705703)15.527544140762, 2.2423577800088, 8.8115454839016
10given(0.99778623885121, 0.035174826543103, -0.05643893281074), (-0.0098064186519906, -0.76157102379196, -0.64800726066433), (-0.06577579883494, 0.64712619116995, -0.75954014837235)30.846197004725, -3.02608196511, 14.203423121308
11given(0.9999411888394, -0.010718871703016, 0.0016506519536351), (0.00056731477278679, 0.20369008262978, 0.97903525390673), (-0.010830374712185, -0.97897673926794, 0.20368418435388)-14.78040616409, -12.467400850919, 0.92468571072211
12given(0.99673156752892, 0.068109957069974, -0.043442099848651), (0.030963496364364, -0.81877504464223, -0.57327889213193), (-0.07461530797516, 0.57006004948518, -0.81820785610792)-44.241913308298, -3.0588476248176, 15.096776631504
13given(0.99558409842405, 0.068954916598724, -0.063698684774691), (0.016596690173786, -0.79716000796403, -0.60353995027509), (-0.092395090997508, 0.59981758992184, -0.79478425121533)-44.58856877906, -3.8961407438523, 15.395888541596

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Components

#1: Antibody
TFPI-23-Fab Heavy chain


Mass: 23216.029 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#2: Antibody
TFPI-23-Fab Light chain


Mass: 22759.031 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#3: Protein
Tissue factor pathway inhibitor


Mass: 7997.842 Da / Num. of mol.: 6 / Fragment: K2 domain
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Macaca fascicularis (crab-eating macaque)
Production host: Homo sapiens (human) / References: UniProt: Q2PFV4
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.7 Å3/Da / Density % sol: 54.51 %
Crystal growTemperature: 291 K / Method: vapor diffusion, sitting drop
Details: 100 mM ammonium acetate, 17 % PEG 1000, 100 mM bis-tris pH 5.5

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 17-ID / Wavelength: 1 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Aug 12, 2013
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 3.11→45.53 Å / Num. obs: 559983 / % possible obs: 98.45 % / Redundancy: 1.8 % / Rmerge(I) obs: 0.149 / Rrim(I) all: 0.211 / Net I/σ(I): 5
Reflection shellResolution: 3.11→3.19 Å / Rmerge(I) obs: 1.493 / Num. unique obs: 4387 / Rrim(I) all: 2.109

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Processing

Software
NameVersionClassification
PHENIX2.0_5936refinement
autoPROCdata reduction
autoPROCdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 3.11→44.2 Å / SU ML: 0.4801 / Cross valid method: FREE R-VALUE / σ(F): 1.97 / Phase error: 29.2821
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflectionSelection details
Rfree0.2733 3049 5.06 %RANDOM
Rwork0.2258 57178 --
obs0.2282 60227 98.4 %-
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 85.89 Å2
Refinement stepCycle: LAST / Resolution: 3.11→44.2 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms18693 0 0 0 18693
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.003819149
X-RAY DIFFRACTIONf_angle_d0.804426038
X-RAY DIFFRACTIONf_chiral_restr0.05042876
X-RAY DIFFRACTIONf_plane_restr0.00663361
X-RAY DIFFRACTIONf_dihedral_angle_d14.75236782
Refine LS restraints NCS
Ens-IDDom-IDAsym-IDAuth asym-IDRefine-IDTypeRms dev position (Å)
ens_1d_2AAX-RAY DIFFRACTIONTorsion NCS1.3685700594937
ens_1d_3AAX-RAY DIFFRACTIONTorsion NCS3.6964306625165
ens_1d_4AAX-RAY DIFFRACTIONTorsion NCS1.6682951030919
ens_2d_2BBX-RAY DIFFRACTIONTorsion NCS1.863253850586
ens_2d_3BBX-RAY DIFFRACTIONTorsion NCS4.3038110216106
ens_2d_4BBX-RAY DIFFRACTIONTorsion NCS2.0776575034973
ens_3d_2CCX-RAY DIFFRACTIONTorsion NCS0.94447603375113
ens_3d_3CCX-RAY DIFFRACTIONTorsion NCS1.6897901389058
ens_3d_4CCX-RAY DIFFRACTIONTorsion NCS0.80892559056609
ens_3d_5CCX-RAY DIFFRACTIONTorsion NCS1.0039713680364
ens_3d_6CCX-RAY DIFFRACTIONTorsion NCS0.85935964563227
ens_4d_2MMX-RAY DIFFRACTIONTorsion NCS0.89496415245455
ens_5d_2NNX-RAY DIFFRACTIONTorsion NCS0.98001458046878
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.11-3.150.37491480.35222536X-RAY DIFFRACTION96.93
3.15-3.210.35591390.32542582X-RAY DIFFRACTION98.23
3.21-3.260.36951310.31052637X-RAY DIFFRACTION98.02
3.26-3.320.34011410.30522562X-RAY DIFFRACTION98.08
3.32-3.380.36281260.30282628X-RAY DIFFRACTION97.76
3.38-3.450.30621270.28162543X-RAY DIFFRACTION98.02
3.45-3.530.34821360.27352591X-RAY DIFFRACTION97.95
3.53-3.610.34541440.2842641X-RAY DIFFRACTION98.44
3.61-3.70.32771340.26422573X-RAY DIFFRACTION98.4
3.7-3.80.29421350.24232612X-RAY DIFFRACTION98.42
3.8-3.910.28991380.23962604X-RAY DIFFRACTION98.21
3.91-4.040.27171370.2132566X-RAY DIFFRACTION98.51
4.04-4.180.25061490.20222627X-RAY DIFFRACTION98.79
4.18-4.350.23671430.18722600X-RAY DIFFRACTION98.35
4.35-4.550.23531290.17912592X-RAY DIFFRACTION98.66
4.55-4.790.22961280.17552646X-RAY DIFFRACTION98.93
4.79-5.090.23241270.17632608X-RAY DIFFRACTION99.24
5.09-5.480.23831380.18022611X-RAY DIFFRACTION99.24
5.48-6.030.19961380.20282644X-RAY DIFFRACTION98.79
6.03-6.90.28761570.21982598X-RAY DIFFRACTION98.85
6.9-8.680.2391620.20792591X-RAY DIFFRACTION98.92
8.69-44.20.25791420.22232586X-RAY DIFFRACTION98.24
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.2698735696567-0.14429608684771.19232413281240.92031231962947-0.428990694377520.85617150542823-0.069975581006778-0.40348480302031-0.198924430424620.675001495577650.266168219160480.326007333758110.28533579013345-0.27990857560389-0.0809928230684520.911378455637750.14406474882149-0.105725159596250.428543263586270.0558343271432020.60756302530461-37.052747423003-42.36345281467327.714862797116
22.95212049563420.0776981990516160.200200006041430.458927636393631.27818837726673.045924399634-0.72022504690205-0.53340977916844-0.873671182788351.67788280877040.675681507869111.16752391383321.1469738048058-1.70684630165050.778635659924580.931675700407710.0679017068498880.246723933081880.537433655831530.0939647562941410.48818249898487-48.000995491362-35.83500694206529.636360697025
32.72451817969310.972589612921550.801893035996834.3401231032311-0.485483187774623.12021496343850.458706118186360.58301343891603-0.624571388596530.41877709529161-0.09070475713259-0.272519593476140.566479609350810.081555975498231-0.13551784778430.383352108545540.0238708742354810.00780450690140220.381865559307580.00840312688942140.29651092961053-39.454897521597-31.70526035502921.13894954545
41.1734270425614-0.626661696911091.67807630929425.77675363820360.482579827687172.697832231415-0.936611306390220.148259036084080.466216214103390.788884755427020.85497490350741-0.7129063877665-0.15038634309577-0.28310352626419-0.174911403750610.37739875607294-0.0547603738044150.0656198771806180.593442489146720.00414513274697110.45954628590756-41.529290479064-36.78824712408316.074177173098
52.3894750528249-0.044047675861745-0.924939059443152.97482381800261.51316286526723.04363725990550.1246857627789-0.168755474571930.0667135139129070.828551800196290.061107511058203-0.461088110112260.23945599675117-0.42727093910359-0.15282033019350.547403963702860.00700326481751730.059585864871640.470977798400770.107164854951350.46691756696352-39.30760915334-35.50416275481825.214779785244
62.61245777246330.025438967246993-0.839062019871681.2264101904945-0.794173737161971.21330775911970.86842719493935-0.30261826304396-0.53110152636487-0.12801801255058-0.434605668590790.210801533866960.913148291710580.68376800786163-0.0479211393705250.693151825441060.19227769777233-0.0105747268081880.73178586263644-0.0767361746025340.60354056200821-8.6820308841566-52.99558860650329.172341149269
72.99332887041420.828212505650472.31910376716791.69555304460471.8678037911993.100891317725-0.27392380214257-0.75450089885523-0.162118502084140.53897888197282-0.11871100444669-0.371294242193540.12614589102977-0.0934617116696320.225801608052650.739245231002260.23788284829876-0.140105228585960.856729364868030.0352382416166410.63099848970168-11.428446554808-49.0894689271734.152793238559
83.1551924220882-2.65751485345733.02741404720322.5303961199472-3.04621835925225.2179047488267-0.5299424016742-0.81184583420202-0.463514763964881.4643963039760.80987552767164-1.38955143590190.593617430247821.4704069939365-0.303638351515661.39489237722270.281224949481-0.462628465919771.37872948436240.0832475757212560.95274338371541-0.018435862334179-50.51678503306344.863500946677
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917.483007720157-2.44352933021480.330138538849741.3878527121119-0.849067936474532.8836549880199-0.49592876621596-0.527815205390680.258653780985720.763133270931150.0565068131052120.0601369978368390.0509906736211910.319976358583180.360521169344610.39696948573360.105005375943350.062998036969430.75238513572775-0.0370625105713710.75238971454835-48.712476750507-0.2107940139336927.055797376686
924.66901947605192.43431109396831.002834859571.91065988836272.20587383609524.70738613877170.4896380382811-0.142405478493230.50679509145554-0.17754297628758-0.065466209083874-0.34411927131077-0.194094809192480.181145791748690.573164719640410.70244725714377-0.13595095213525-0.385791065308261.11118521581660.295051574224681.7514579277624-32.31813262443920.10417211588828.026204686371
931.769581195799-2.08707293211520.23827847255062.78966550569021.18380836556373.18581103628210.1712717516611-0.6013642359299-0.402537577530770.46242975615455-0.0362900843102180.22013885761353-0.0057466676676162-0.34753483844496-0.221784550716530.3885758518656-0.0553962291713390.0622720388277890.446701085200360.0293397461047580.59290326577719-65.358006331853-7.732772329762721.583420109064
943.63585019010791.10645617621211.33960089483894.46103803096271.62944475100722.95214491229640.2438216392366-0.34385156096323-0.010084367263425-0.20478308977192-0.23235688927636-0.136881109699280.37234144148797-0.71121171501062-0.168135947175460.389285621362180.0133062810792690.136887395073120.541154290203170.100188939399140.6768076361214-70.251043657583-10.21606506861717.420590648344
951.03718153807171.54736961791461.70305377280234.58463995895363.45654583965175.871856769859-0.23038451746097-0.140486508913490.26745517965582-0.758406630031490.76019174731656-0.5845784169224-0.21311003590625-0.21085020787391-0.810239008267330.36371146731675-0.0148819773154450.109251185506870.510440154654010.0696842277777080.84739632441883-60.719116417397-5.848536379635820.620982693235
965.7243452213873-2.08059140173982.85987508884686.4357074028328-0.508833609620489.2949835677492-0.1346198755860.9811356435268-0.856456891182460.24631635297991.0540744279987-0.20695325754003-0.244123330393810.055170984279294-0.972757432109090.498247607034550.0829761191093930.0704918869743430.506710184289020.0564349216854790.60985142718073-62.70554579553-14.42021532116711.52738605949
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 1 through 17 )AA1 - 171 - 17
22chain 'A' and (resid 18 through 33 )AA18 - 3318 - 33
33chain 'A' and (resid 34 through 60 )AA34 - 6034 - 60
44chain 'A' and (resid 61 through 73 )AA61 - 7361 - 73
55chain 'A' and (resid 74 through 118 )AA74 - 11874 - 118
66chain 'A' and (resid 119 through 142 )AA119 - 142119 - 135
77chain 'A' and (resid 143 through 184 )AA143 - 184136 - 177
88chain 'A' and (resid 185 through 200 )AA185 - 200178 - 193
99chain 'A' and (resid 201 through 220 )AA201 - 220194 - 213
1010chain 'B' and (resid 1 through 23 )BB1 - 231 - 23
1111chain 'B' and (resid 24 through 94 )BB24 - 9424 - 94
1212chain 'B' and (resid 95 through 143 )BB95 - 14395 - 143
1313chain 'B' and (resid 144 through 179 )BB144 - 179144 - 179
1414chain 'B' and (resid 180 through 193 )BB180 - 193180 - 193
1515chain 'B' and (resid 194 through 215 )BB194 - 215194 - 215
1616chain 'C' and (resid 93 through 109 )CC93 - 1091 - 17
1717chain 'C' and (resid 110 through 127 )CC110 - 12718 - 35
1818chain 'C' and (resid 128 through 148 )CC128 - 14836 - 56
1919chain 'D' and (resid 1 through 33 )DD1 - 331 - 33
2020chain 'D' and (resid 34 through 57 )DD34 - 5734 - 57
2121chain 'D' and (resid 58 through 73 )DD58 - 7358 - 73
2222chain 'D' and (resid 74 through 164 )DD74 - 16474 - 156
2323chain 'D' and (resid 165 through 201 )DD165 - 201157 - 193
2424chain 'D' and (resid 202 through 220 )DD202 - 220194 - 212
2525chain 'E' and (resid 1 through 64 )EE1 - 641 - 64
2626chain 'E' and (resid 65 through 94 )EE65 - 9465 - 94
2727chain 'E' and (resid 95 through 121 )EE95 - 12195 - 121
2828chain 'E' and (resid 122 through 136 )EE122 - 136122 - 136
2929chain 'E' and (resid 137 through 177 )EE137 - 177137 - 177
3030chain 'E' and (resid 178 through 193 )EE178 - 193178 - 193
3131chain 'E' and (resid 194 through 216 )EE194 - 216194 - 216
3232chain 'F' and (resid 93 through 98 )FF93 - 981 - 6
3333chain 'F' and (resid 99 through 109 )FF99 - 1097 - 17
3434chain 'F' and (resid 110 through 116 )FF110 - 11618 - 24
3535chain 'F' and (resid 117 through 127 )FF117 - 12725 - 35
3636chain 'F' and (resid 128 through 139 )FF128 - 13936 - 47
3737chain 'F' and (resid 140 through 148 )FF140 - 14848 - 56
3838chain 'G' and (resid 1 through 39 )GG1 - 391 - 39
3939chain 'G' and (resid 40 through 73 )GG40 - 7340 - 73
4040chain 'G' and (resid 74 through 126 )GG74 - 12674 - 126
4141chain 'G' and (resid 127 through 164 )GG127 - 164127 - 156
4242chain 'G' and (resid 165 through 201 )GG165 - 201157 - 193
4343chain 'G' and (resid 202 through 220 )GG202 - 220194 - 212
4444chain 'H' and (resid 1 through 107 )HH1 - 1071 - 107
4545chain 'H' and (resid 108 through 154 )HH108 - 154108 - 154
4646chain 'H' and (resid 155 through 179 )HH155 - 179155 - 177
4747chain 'H' and (resid 180 through 193 )HH180 - 193178 - 191
4848chain 'H' and (resid 194 through 214 )HH194 - 214192 - 212
4949chain 'I' and (resid 93 through 109 )II93 - 1091 - 17
5050chain 'I' and (resid 110 through 115 )II110 - 11518 - 23
5151chain 'I' and (resid 116 through 139 )II116 - 13924 - 47
5252chain 'I' and (resid 140 through 148 )II140 - 14848 - 56
5353chain 'J' and (resid 1 through 127 )JJ1 - 1271 - 127
5454chain 'J' and (resid 128 through 220 )JJ128 - 220128 - 212
5555chain 'K' and (resid 1 through 119 )KK1 - 1191 - 119
5656chain 'K' and (resid 120 through 214 )KK120 - 214120 - 212
5757chain 'L' and (resid 93 through 98 )LL93 - 981 - 6
5858chain 'L' and (resid 99 through 109 )LL99 - 1097 - 17
5959chain 'L' and (resid 110 through 116 )LL110 - 11618 - 24
6060chain 'L' and (resid 117 through 148 )LL117 - 14825 - 56
6161chain 'M' and (resid 1 through 7 )MM1 - 71 - 7
6262chain 'M' and (resid 8 through 17 )MM8 - 178 - 17
6363chain 'M' and (resid 18 through 60 )MM18 - 6018 - 60
6464chain 'M' and (resid 61 through 73 )MM61 - 7361 - 73
6565chain 'M' and (resid 74 through 109 )MM74 - 10974 - 109
6666chain 'M' and (resid 110 through 120 )MM110 - 120110 - 120
6767chain 'N' and (resid 1 through 8 )NN1 - 81 - 8
6868chain 'N' and (resid 9 through 16 )NN9 - 169 - 16
6969chain 'N' and (resid 17 through 34 )NN17 - 3417 - 34
7070chain 'N' and (resid 35 through 50 )NN35 - 5035 - 50
7171chain 'N' and (resid 51 through 71 )NN51 - 7151 - 71
7272chain 'N' and (resid 72 through 85 )NN72 - 8572 - 85
7373chain 'N' and (resid 86 through 100 )NN86 - 10086 - 100
7474chain 'N' and (resid 101 through 106 )NN101 - 106101 - 106
7575chain 'N' and (resid 107 through 113 )NN107 - 113107 - 113
7676chain 'O' and (resid 93 through 109 )OO93 - 1091 - 17
7777chain 'O' and (resid 110 through 148 )OO110 - 14818 - 56
7878chain 'P' and (resid 1 through 7 )PP1 - 71 - 7
7979chain 'P' and (resid 8 through 25 )PP8 - 258 - 25
8080chain 'P' and (resid 26 through 32 )PP26 - 3226 - 32
8181chain 'P' and (resid 33 through 51 )PP33 - 5133 - 51
8282chain 'P' and (resid 52 through 60 )PP52 - 6052 - 60
8383chain 'P' and (resid 61 through 73 )PP61 - 7361 - 73
8484chain 'P' and (resid 74 through 83 )PP74 - 8374 - 83
8585chain 'P' and (resid 84 through 92 )PP84 - 9284 - 92
8686chain 'P' and (resid 93 through 109 )PP93 - 10993 - 109
8787chain 'P' and (resid 110 through 120 )PP110 - 120110 - 120
8888chain 'Q' and (resid 1 through 20 )QQ1 - 201 - 20
8989chain 'Q' and (resid 21 through 64 )QQ21 - 6421 - 64
9090chain 'Q' and (resid 65 through 94 )QQ65 - 9465 - 94
9191chain 'Q' and (resid 95 through 107 )QQ95 - 10795 - 107
9292chain 'Q' and (resid 108 through 113 )QQ108 - 113108 - 113
9393chain 'R' and (resid 93 through 116 )RR93 - 1161 - 24
9494chain 'R' and (resid 117 through 127 )RR117 - 12725 - 35
9595chain 'R' and (resid 128 through 139 )RR128 - 13936 - 47
9696chain 'R' and (resid 140 through 148 )RR140 - 14848 - 56

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