- PDB-2yz1: Crystal structure of the ligand-binding domain of murine SHPS-1/S... -
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基本情報
登録情報
データベース: PDB / ID: 2yz1
タイトル
Crystal structure of the ligand-binding domain of murine SHPS-1/SIRP alpha
要素
Tyrosine-protein phosphatase non-receptor type substrate 1
キーワード
IMMUNE SYSTEM / BETA-SANDWICH / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / Alternative splicing / Glycoprotein / Immunoglobulin domain / Membrane / Phosphorylation / Polymorphism / SH3-binding / Transmembrane
機能・相同性
機能・相同性情報
Signal regulatory protein family interactions / negative regulation of I-kappaB phosphorylation / cellular response to interleukin-12 / monocyte extravasation / negative regulation of macrophage inflammatory protein 1 alpha production / granulocyte migration / negative regulation of chemokine (C-C motif) ligand 5 production / protein binding involved in heterotypic cell-cell adhesion / protein phosphorylated amino acid binding / regulation of interleukin-1 beta production ...Signal regulatory protein family interactions / negative regulation of I-kappaB phosphorylation / cellular response to interleukin-12 / monocyte extravasation / negative regulation of macrophage inflammatory protein 1 alpha production / granulocyte migration / negative regulation of chemokine (C-C motif) ligand 5 production / protein binding involved in heterotypic cell-cell adhesion / protein phosphorylated amino acid binding / regulation of interleukin-1 beta production / regulation of type II interferon production / GTPase regulator activity / Cell surface interactions at the vascular wall / positive regulation of cell-cell adhesion / cell-cell adhesion mediator activity / protein antigen binding / negative regulation of nitric oxide biosynthetic process / phagocytosis, recognition / negative regulation of interferon-beta production / negative regulation of JNK cascade / regulation of tumor necrosis factor production / regulation of nitric oxide biosynthetic process / negative regulation of phagocytosis / DAP12 interactions / regulation of interleukin-6 production / phagocytosis, engulfment / plasma membrane => GO:0005886 / negative regulation of interleukin-6 production / negative regulation of tumor necrosis factor production / negative regulation of cytokine production involved in inflammatory response / cellular response to interleukin-1 / hematopoietic progenitor cell differentiation / positive regulation of phagocytosis / cytoskeleton organization / Neutrophil degranulation / protein tyrosine kinase binding / cell-matrix adhesion / negative regulation of protein phosphorylation / actin filament organization / negative regulation of ERK1 and ERK2 cascade / negative regulation of inflammatory response / cellular response to type II interferon / SH3 domain binding / cellular response to hydrogen peroxide / cell migration / positive regulation of T cell activation / regulation of gene expression / cellular response to lipopolysaccharide / protein phosphatase binding / cell surface / plasma membrane 類似検索 - 分子機能
構造決定の手法: 分子置換 / 解像度: 1.4→39.75 Å / Cor.coef. Fo:Fc: 0.962 / Cor.coef. Fo:Fc free: 0.957 / SU B: 0.769 / SU ML: 0.032 / 交差検証法: THROUGHOUT / ESU R: 0.067 / ESU R Free: 0.068 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.19914
1954
5 %
RANDOM
Rwork
0.17425
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all
0.17553
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obs
0.17553
37007
99.98 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK