- PDB-2yz1: Crystal structure of the ligand-binding domain of murine SHPS-1/S... -
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Basic information
Entry
Database: PDB / ID: 2yz1
Title
Crystal structure of the ligand-binding domain of murine SHPS-1/SIRP alpha
Components
Tyrosine-protein phosphatase non-receptor type substrate 1
Keywords
IMMUNE SYSTEM / BETA-SANDWICH / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / Alternative splicing / Glycoprotein / Immunoglobulin domain / Membrane / Phosphorylation / Polymorphism / SH3-binding / Transmembrane
Function / homology
Function and homology information
Signal regulatory protein family interactions / negative regulation of I-kappaB phosphorylation / monocyte extravasation / negative regulation of macrophage inflammatory protein 1 alpha production / granulocyte migration / negative regulation of chemokine (C-C motif) ligand 5 production / protein binding involved in heterotypic cell-cell adhesion / protein phosphorylated amino acid binding / regulation of interleukin-1 beta production / GTPase regulator activity ...Signal regulatory protein family interactions / negative regulation of I-kappaB phosphorylation / monocyte extravasation / negative regulation of macrophage inflammatory protein 1 alpha production / granulocyte migration / negative regulation of chemokine (C-C motif) ligand 5 production / protein binding involved in heterotypic cell-cell adhesion / protein phosphorylated amino acid binding / regulation of interleukin-1 beta production / GTPase regulator activity / Cell surface interactions at the vascular wall / phagocytosis, recognition / negative regulation of nitric oxide biosynthetic process / negative regulation of interferon-beta production / negative regulation of JNK cascade / regulation of tumor necrosis factor production / regulation of nitric oxide biosynthetic process / regulation of interleukin-6 production / negative regulation of phagocytosis / phagocytosis, engulfment / negative regulation of interleukin-6 production / negative regulation of tumor necrosis factor production / cellular response to interleukin-1 / negative regulation of cytokine production involved in inflammatory response / hematopoietic progenitor cell differentiation / positive regulation of phagocytosis / cytoskeleton organization / protein tyrosine kinase binding / Neutrophil degranulation / cell-matrix adhesion / negative regulation of protein phosphorylation / actin filament organization / cell motility / cellular response to type II interferon / negative regulation of ERK1 and ERK2 cascade / SH3 domain binding / cellular response to hydrogen peroxide / positive regulation of T cell activation / cell migration / cellular response to lipopolysaccharide / protein phosphatase binding / cell surface / plasma membrane Similarity search - Function
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