Entry Database : PDB / ID : 2ykt Structure visualization Downloads & linksTitle Crystal structure of the I-BAR domain of IRSp53 (BAIAP2) in complex with an EHEC derived Tir peptide ComponentsBRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 TRANSLOCATED INTIMIN RECEPTOR PROTEIN DetailsKeywords SIGNALING PROTEIN / NPY MOTIF / BINDING POCKETFunction / homology Function and homology informationFunction Domain/homology Component
neuron projection branch point / dendritic spine cytoplasm / plasma membrane organization / actin crosslink formation / positive regulation of dendritic spine morphogenesis / cellular response to L-glutamate / protein localization to synapse / cadherin binding involved in cell-cell adhesion / cytoskeletal anchor activity / regulation of modification of postsynaptic actin cytoskeleton ... neuron projection branch point / dendritic spine cytoplasm / plasma membrane organization / actin crosslink formation / positive regulation of dendritic spine morphogenesis / cellular response to L-glutamate / protein localization to synapse / cadherin binding involved in cell-cell adhesion / cytoskeletal anchor activity / regulation of modification of postsynaptic actin cytoskeleton / presynaptic cytosol / neuron projection terminus / proline-rich region binding / postsynaptic cytosol / positive regulation of actin filament polymerization / dendrite development / positive regulation of excitatory postsynaptic potential / CDC42 GTPase cycle / actin filament bundle assembly / excitatory synapse / : / RAC3 GTPase cycle / RHO GTPases Activate WASPs and WAVEs / postsynaptic density, intracellular component / cellular response to epidermal growth factor stimulus / ruffle / RAC1 GTPase cycle / axonogenesis / dendritic shaft / synaptic membrane / secretory granule / filopodium / transcription coregulator binding / PDZ domain binding / regulation of actin cytoskeleton organization / adherens junction / FCGR3A-mediated phagocytosis / Schaffer collateral - CA1 synapse / regulation of synaptic plasticity / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / insulin receptor signaling pathway / lamellipodium / regulation of cell shape / scaffold protein binding / microtubule / membrane => GO:0016020 / neuronal cell body / glutamatergic synapse / host cell plasma membrane / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Translocated intimin receptor, central domain / Translocated intimin receptor, N-terminal / Translocated intimin receptor / Translocated intimin receptor, C-terminal / Translocated intimin receptor, central domain superfamily / Translocated intimin receptor (Tir) intimin-binding domain / Translocated intimin receptor (Tir) C-terminus / Translocated intimin receptor (Tir) N-terminus / I-BAR domain containing protein IRSp53 / IRSp53, SH3 domain ... Translocated intimin receptor, central domain / Translocated intimin receptor, N-terminal / Translocated intimin receptor / Translocated intimin receptor, C-terminal / Translocated intimin receptor, central domain superfamily / Translocated intimin receptor (Tir) intimin-binding domain / Translocated intimin receptor (Tir) C-terminus / Translocated intimin receptor (Tir) N-terminus / I-BAR domain containing protein IRSp53 / IRSp53, SH3 domain / I-BAR domain containing protein IRSp53/IRTKS/Pinkbar / IMD/I-BAR domain / IRSp53/MIM homology domain / IMD domain profile. / Arfaptin homology (AH) domain/BAR domain / AH/BAR domain superfamily / Variant SH3 domain / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)ESCHERICHIA COLI O157\:H7 (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.11 Å DetailsAuthors de Groot, J.C. / Schlueter, K. / Carius, Y. / Quedenau, C. / Vingadassalom, D. / Faix, J. / Weiss, S.M. / Reichelt, J. / Standfuss-Gabisch, C. / Lesser, C.F. ...de Groot, J.C. / Schlueter, K. / Carius, Y. / Quedenau, C. / Vingadassalom, D. / Faix, J. / Weiss, S.M. / Reichelt, J. / Standfuss-Gabisch, C. / Lesser, C.F. / Leong, J.M. / Heinz, D.W. / Buessow, K. / Stradal, T.E.B. CitationJournal : Structure / Year : 2011Title : Structural Basis for Complex Formation between Human Irsp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. Coli.Authors: De Groot, J.C. / Schluter, K. / Carius, Y. / Quedenau, C. / Vingadassalom, D. / Faix, J. / Weiss, S.M. / Reichelt, J. / Standfuss-Gabisch, C. / Lesser, C.F. / Leong, J.M. / Heinz, D.W. / ... Authors : De Groot, J.C. / Schluter, K. / Carius, Y. / Quedenau, C. / Vingadassalom, D. / Faix, J. / Weiss, S.M. / Reichelt, J. / Standfuss-Gabisch, C. / Lesser, C.F. / Leong, J.M. / Heinz, D.W. / Bussow, K. / Stradal, T.E.B. History Deposition May 30, 2011 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 7, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Oct 26, 2011 Group : Database referencesRevision 1.2 Apr 1, 2015 Group : Database referencesRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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