Entry | Database: PDB / ID: 2xtd |
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Title | Structure of the TBL1 tetramerisation domain |
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Components | TBL1 F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X |
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Keywords | TRANSCRIPTION / N-COR REPRESSOR COMPLEX / PROTEASOME |
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Function / homology | Function and homology information
Loss of MECP2 binding ability to the NCoR/SMRT complex / Notch-HLH transcription pathway / histone deacetylase complex / Regulation of MECP2 expression and activity / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / RORA activates gene expression / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) ...Loss of MECP2 binding ability to the NCoR/SMRT complex / Notch-HLH transcription pathway / histone deacetylase complex / Regulation of MECP2 expression and activity / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / RORA activates gene expression / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / HDACs deacetylate histones / sensory perception of sound / PPARA activates gene expression / HCMV Early Events / Heme signaling / Transcriptional activation of mitochondrial biogenesis / Transcriptional regulation of white adipocyte differentiation / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / mitotic spindle / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / positive regulation of canonical Wnt signaling pathway / transcription corepressor activity / Circadian Clock / histone binding / proteasome-mediated ubiquitin-dependent protein catabolic process / transcription cis-regulatory region binding / protein stabilization / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / proteolysis / nucleoplasm / identical protein binding / nucleusSimilarity search - Function F-box-like/WD repeat-containing protein Ebi-like / Mitochondrial Import Receptor Subunit Tom20; Chain A - #30 / LisH / Lissencephaly type-1-like homology motif / Mitochondrial Import Receptor Subunit Tom20; Chain A / LIS1 homology (LisH) motif profile. / LIS1 homology motif / Quinoprotein alcohol dehydrogenase-like superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site ...F-box-like/WD repeat-containing protein Ebi-like / Mitochondrial Import Receptor Subunit Tom20; Chain A - #30 / LisH / Lissencephaly type-1-like homology motif / Mitochondrial Import Receptor Subunit Tom20; Chain A / LIS1 homology (LisH) motif profile. / LIS1 homology motif / Quinoprotein alcohol dehydrogenase-like superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.2 Å |
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Authors | Oberoi, J. / Fairall, L. / Watson, P.J. / Greenwood, J.A. / Schwabe, J.W.R. |
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Citation | Journal: Nat.Struct.Mol.Biol. / Year: 2011 Title: Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery. Authors: Oberoi, J. / Fairall, L. / Watson, P.J. / Yang, J.C. / Czimmerer, Z. / Kampmann, T. / Goult, B.T. / Greenwood, J.A. / Gooch, J.T. / Kallenberger, B.C. / Nagy, L. / Neuhaus, D. / Schwabe, J.W.R. |
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History | Deposition | Oct 6, 2010 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jan 19, 2011 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 8, 2011 | Group: Version format compliance |
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Revision 1.2 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.3 | Dec 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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