Entry Database : PDB / ID : 2x22 Structure visualization Downloads & linksTitle crystal structure of M. tuberculosis InhA inhibited by PT70 ComponentsENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] Details Keywords OXIDOREDUCTASE / FATTY ACID BIOSYNTHESIS / LIPID SYNTHESIS / ANTIBIOTIC RESISTANCEFunction / homology Function and homology informationFunction Domain/homology Component
enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) / trans-2-enoyl-CoA reductase (NADH) activity / mycolic acid biosynthetic process / fatty acid elongation / enoyl-[acyl-carrier-protein] reductase (NADH) / enoyl-[acyl-carrier-protein] reductase (NADH) activity / NAD+ binding / peptidoglycan-based cell wall / fatty acid binding / fatty acid biosynthetic process ... enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) / trans-2-enoyl-CoA reductase (NADH) activity / mycolic acid biosynthetic process / fatty acid elongation / enoyl-[acyl-carrier-protein] reductase (NADH) / enoyl-[acyl-carrier-protein] reductase (NADH) activity / NAD+ binding / peptidoglycan-based cell wall / fatty acid binding / fatty acid biosynthetic process / response to antibiotic / plasma membrane Similarity search - Function Enoyl-[acyl-carrier-protein] reductase (NADH) / Enoyl-(Acyl carrier protein) reductase / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology NICOTINAMIDE-ADENINE-DINUCLEOTIDE / 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL / Enoyl-[acyl-carrier-protein] reductase [NADH] / Enoyl-[acyl-carrier-protein] reductase [NADH] Similarity search - ComponentBiological species MYCOBACTERIUM TUBERCULOSIS (bacteria)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Luckner, S.R. / Liu, N. / am Ende, C.W. / Tonge, P.J. / Kisker, C. CitationJournal : J.Biol.Chem. / Year : 2010Title : A Slow, Tight Binding Inhibitor of Inha, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis.Authors : Luckner, S.R. / Liu, N. / Am Ende, C.W. / Tonge, P.J. / Kisker, C. History Deposition Jan 10, 2010 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 2, 2010 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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