Entry | Database: PDB / ID: 2w9g |
---|
Title | Wild-type Staphylococcus aureus DHFR in complex with NADPH and trimethoprim |
---|
Components | DIHYDROFOLATE REDUCTASE |
---|
Keywords | OXIDOREDUCTASE / ONE-CARBON METABOLISM |
---|
Function / homology | Function and homology information
dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / cytosolSimilarity search - Function Dihydrofolate Reductase, subunit A / Dihydrofolate Reductase, subunit A / Dihydrofolate reductase / Dihydrofolate reductase conserved site / Dihydrofolate reductase (DHFR) domain signature. / Dihydrofolate reductase domain / Dihydrofolate reductase / Dihydrofolate reductase (DHFR) domain profile. / Dihydrofolate reductase-like domain superfamily / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_bacteria.gif) STAPHYLOCOCCUS AUREUS (bacteria) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.95 Å |
---|
Authors | Soutter, H.H. / Miller, J.R. |
---|
Citation | Journal: Proteins / Year: 2009 Title: Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim. Authors: Heaslet, H. / Harris, M. / Fahnoe, K. / Sarver, R. / Putz, H. / Chang, J. / Subramanian, C. / Barreiro, G. / Miller, J.R. |
---|
History | Deposition | Jan 23, 2009 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Mar 24, 2009 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | May 8, 2011 | Group: Version format compliance |
---|
Revision 1.2 | Jul 13, 2011 | Group: Version format compliance |
---|
Revision 1.3 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|