Entry Database : PDB / ID : 2vpp Structure visualization Downloads & linksTitle Drosophila melanogaster deoxyribonucleoside kinase successfully activates gemcitabine in transduced cancer cell lines ComponentsDEOXYNUCLEOSIDE KINASE Details Keywords TRANSFERASE / KINASE / CANCER / ATP-BINDING / PHOSPHOPROTEIN / NUCLEOSIDE ANALOGS / NUCLEOTIDE-BINDING / STRUCTURE-FUNCTION RELATIONSHIP / GEMCITABINE / GENE THERAPY / DNA SYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
deoxynucleoside kinase / Pyrimidine salvage / deoxynucleoside kinase activity / nucleoside salvage / uridine kinase activity / deoxycytidine kinase activity / nucleoside phosphate biosynthetic process / thymidine kinase activity / deoxyguanosine kinase activity / deoxyadenosine kinase activity ... deoxynucleoside kinase / Pyrimidine salvage / deoxynucleoside kinase activity / nucleoside salvage / uridine kinase activity / deoxycytidine kinase activity / nucleoside phosphate biosynthetic process / thymidine kinase activity / deoxyguanosine kinase activity / deoxyadenosine kinase activity / cytidine kinase activity / DNA biosynthetic process / kinase activity / mitochondrion / ATP binding / cytoplasm Similarity search - Function Deoxynucleoside kinase / : / Deoxynucleoside kinase domain / Deoxynucleoside kinase / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species DROSOPHILA MELANOGASTER (fruit fly)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Knecht, W. / Mikkelsen, N.E. / Clausen, A. / Willer, M. / Gojkovic, Z. / Piskur, J. CitationJournal : Biochem.Biophys.Res.Commun. / Year : 2009Title : Drosophila Melanogaster Deoxyribonucleoside Kinase Activates Gemcitabine.Authors : Knecht, W. / Mikkelsen, N.E. / Clausen, A. / Willer, M. / Eklund, H. / Gojkovic, Z. / Piskur, J. History Deposition Mar 3, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 24, 2009 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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