Entry Database : PDB / ID : 2vnu Structure visualization Downloads & linksTitle Crystal structure of Sc Rrp44 Components5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP)-3'EXOSOME COMPLEX EXONUCLEASE RRP44 DetailsKeywords HYDROLASE/RNA / HYDROLASE-RNA COMPLEX / RNA DEGRADATION / RNA-BINDING / RNA PROCESSINGFunction / homology Function and homology informationFunction Domain/homology Component
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / mRNA decay by 3' to 5' exoribonuclease / nuclear mRNA surveillance of mRNA 3'-end processing / regulatory ncRNA 3'-end processing / nuclear polyadenylation-dependent CUT catabolic process / TRAMP-dependent tRNA surveillance pathway / cytoplasmic exosome (RNase complex) / nuclear polyadenylation-dependent rRNA catabolic process / exosome (RNase complex) ... Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / mRNA decay by 3' to 5' exoribonuclease / nuclear mRNA surveillance of mRNA 3'-end processing / regulatory ncRNA 3'-end processing / nuclear polyadenylation-dependent CUT catabolic process / TRAMP-dependent tRNA surveillance pathway / cytoplasmic exosome (RNase complex) / nuclear polyadenylation-dependent rRNA catabolic process / exosome (RNase complex) / nuclear exosome (RNase complex) / exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rRNA catabolic process / nuclear mRNA surveillance / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / RNA catabolic process / nonfunctional rRNA decay / RNA processing / RNA endonuclease activity / mRNA processing / Hydrolases; Acting on ester bonds; Exoribonucleases producing 5'-phosphomonoesters / 3'-5'-RNA exonuclease activity / endonuclease activity / tRNA binding / nucleolus / mitochondrion / nucleus Similarity search - Function OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #690 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #700 / Exosome complex exonuclease RRP44, S1 domain / S1 domain / PIN domain / Rrp44-like cold shock domain / Rrp44-like cold shock domain / Dis3-like cold-shock domain 2 / Dis3-like cold-shock domain 2 (CSD2) / Ribonuclease II/R, conserved site ... OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #690 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #700 / Exosome complex exonuclease RRP44, S1 domain / S1 domain / PIN domain / Rrp44-like cold shock domain / Rrp44-like cold shock domain / Dis3-like cold-shock domain 2 / Dis3-like cold-shock domain 2 (CSD2) / Ribonuclease II/R, conserved site / Ribonuclease II family signature. / : / Ribonuclease II/R / RNB domain / RNB / Large family of predicted nucleotide-binding domains / PIN domain / PIN-like domain superfamily / S1 domain profile. / Ribosomal protein S1-like RNA-binding domain / S1 domain / Nucleic acid-binding proteins / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Nucleic acid-binding, OB-fold / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species SACCHAROMYCES CEREVISIAE (brewer's yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.3 Å DetailsAuthors Lorentzen, E. / Basquin, J. / Conti, E. CitationJournal : Mol.Cell / Year : 2008Title : Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the Rnase II Nuclease FamilyAuthors : Lorentzen, E. / Basquin, J. / Tomecki, R. / Dziembowski, A. / Conti, E. History Deposition Feb 7, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 8, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Refinement description / Version format compliance
Show all Show less Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "DB" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "DB" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 5-STRANDED BARREL THIS IS REPRESENTED BY A 6-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.