Entry Database : PDB / ID : 2uxw Structure visualization Downloads & linksTitle Crystal structure of human very long chain acyl-CoA dehydrogenase (ACADVL) ComponentsVERY-LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE Details Keywords OXIDOREDUCTASE / FATTY ACID METABOLISM / TRANSIT PEPTIDE / DISEASE MUTATION / LIPID METABOLISM / COENZYME A DEHYDROGENASE / VERY LONG CHAIN FATTY ACIDS / FAD / FLAVOPROTEIN / MITOCHONDRIAL FATTY ACID BETA-OXIDATION / MITOCHONDRION / CARDIOMYOPATHYFunction / homology Function and homology informationFunction Domain/homology Component
energy derivation by oxidation of organic compounds / very-long-chain acyl-CoA dehydrogenase / very-long-chain fatty acyl-CoA dehydrogenase activity / Beta oxidation of palmitoyl-CoA to myristoyl-CoA / negative regulation of fatty acid oxidation / long-chain fatty acyl-CoA dehydrogenase activity / fatty acid beta-oxidation using acyl-CoA dehydrogenase / acyl-CoA dehydrogenase activity / fatty-acyl-CoA binding / negative regulation of fatty acid biosynthetic process ... energy derivation by oxidation of organic compounds / very-long-chain acyl-CoA dehydrogenase / very-long-chain fatty acyl-CoA dehydrogenase activity / Beta oxidation of palmitoyl-CoA to myristoyl-CoA / negative regulation of fatty acid oxidation / long-chain fatty acyl-CoA dehydrogenase activity / fatty acid beta-oxidation using acyl-CoA dehydrogenase / acyl-CoA dehydrogenase activity / fatty-acyl-CoA binding / negative regulation of fatty acid biosynthetic process / XBP1(S) activates chaperone genes / regulation of cholesterol metabolic process / temperature homeostasis / mitochondrial nucleoid / epithelial cell differentiation / response to cold / mitochondrial membrane / flavin adenine dinucleotide binding / mitochondrial inner membrane / mitochondrial matrix / nucleolus / mitochondrion / nucleoplasm / identical protein binding Similarity search - Function : / ACAD9/ACADV, C-terminal domain / Acyl-CoA dehydrogenases signature 1. / Acyl-CoA dehydrogenases signature 2. / Acyl-CoA dehydrogenase, conserved site / Butyryl-Coa Dehydrogenase, subunit A; domain 1 / Acyl-CoA dehydrogenase/oxidase, N-terminal domain / Acyl-CoA oxidase/dehydrogenase, middle domain superfamily / Butyryl-CoA Dehydrogenase, subunit A, domain 2 / Butyryl-CoA Dehydrogenase, subunit A; domain 2 ... : / ACAD9/ACADV, C-terminal domain / Acyl-CoA dehydrogenases signature 1. / Acyl-CoA dehydrogenases signature 2. / Acyl-CoA dehydrogenase, conserved site / Butyryl-Coa Dehydrogenase, subunit A; domain 1 / Acyl-CoA dehydrogenase/oxidase, N-terminal domain / Acyl-CoA oxidase/dehydrogenase, middle domain superfamily / Butyryl-CoA Dehydrogenase, subunit A, domain 2 / Butyryl-CoA Dehydrogenase, subunit A; domain 2 / Acyl-CoA dehydrogenase/oxidase C-terminal / Acyl-CoA dehydrogenase/oxidase, N-terminal / Acyl-CoA dehydrogenase, C-terminal domain / Acyl-CoA dehydrogenase, N-terminal domain / Acyl-CoA oxidase/dehydrogenase, middle domain / Acyl-CoA dehydrogenase, middle domain / Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily / Butyryl-CoA Dehydrogenase, subunit A, domain 3 / Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily / Acyl-CoA dehydrogenase-like, C-terminal / Butyryl-CoA Dehydrogenase, subunit A; domain 3 / Up-down Bundle / Beta Barrel / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homology FLAVIN-ADENINE DINUCLEOTIDE / TRANS DELTA2 PALMITENOYL-COENZYMEA / Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Similarity search - ComponentBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.45 Å DetailsAuthors Pike, A.C.W. / Hozjan, V. / Smee, C. / Berridge, G. / Burgess, N. / Salah, E. / Bunkoczi, G. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. ...Pike, A.C.W. / Hozjan, V. / Smee, C. / Berridge, G. / Burgess, N. / Salah, E. / Bunkoczi, G. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Oppermann, U. CitationJournal : To be Published Title : Crystal Structure of Human Very Long Chain Acyl- Coa Dehydrogenase (Acadvl)Authors: Pike, A.C.W. / Hozjan, V. / Smee, C. / Berridge, G. / Burgess, N. / Salah, E. / Bunkoczi, G. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Weigelt, J. / ... Authors : Pike, A.C.W. / Hozjan, V. / Smee, C. / Berridge, G. / Burgess, N. / Salah, E. / Bunkoczi, G. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Oppermann, U. History Deposition Mar 30, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 1, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Jan 24, 2018 Group : Database references / Structure summary / Category : audit_author / citation_author / Item : _audit_author.name / _citation_author.nameRevision 1.3 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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