登録情報 | データベース: PDB / ID: 2rq8 |
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タイトル | Solution NMR structure of titin I27 domain mutant |
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要素 | Titin |
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キーワード | TRANSFERASE / Beta-sandwich / Immunoglobulin-like domain / Alternative splicing / ATP-binding / Calcium / Calmodulin-binding / Cardiomyopathy / Coiled coil / Cytoplasm / Disease mutation / Disulfide bond / Immunoglobulin domain / Isopeptide bond / Kelch repeat / Kinase / Limb-girdle muscular dystrophy / Magnesium / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase / TPR repeat / Ubl conjugation / WD repeat |
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機能・相同性 | 機能・相同性情報
sarcomerogenesis / structural molecule activity conferring elasticity / telethonin binding / skeletal muscle myosin thick filament assembly / cardiac myofibril assembly / muscle alpha-actinin binding / detection of muscle stretch / cardiac muscle tissue morphogenesis / regulation of catalytic activity / cardiac muscle hypertrophy ...sarcomerogenesis / structural molecule activity conferring elasticity / telethonin binding / skeletal muscle myosin thick filament assembly / cardiac myofibril assembly / muscle alpha-actinin binding / detection of muscle stretch / cardiac muscle tissue morphogenesis / regulation of catalytic activity / cardiac muscle hypertrophy / mitotic chromosome condensation / Striated Muscle Contraction / actinin binding / M band / I band / cardiac muscle cell development / regulation of protein kinase activity / structural constituent of muscle / sarcomere organization / skeletal muscle thin filament assembly / striated muscle thin filament / striated muscle contraction / cardiac muscle contraction / protein kinase A signaling / condensed nuclear chromosome / muscle contraction / positive regulation of protein secretion / Z disc / response to calcium ion / : / actin filament binding / Platelet degranulation / protein tyrosine kinase activity / protease binding / non-specific serine/threonine protein kinase / calmodulin binding / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / calcium ion binding / positive regulation of gene expression / protein kinase binding / enzyme binding / extracellular exosome / extracellular region / ATP binding / identical protein binding / cytosol類似検索 - 分子機能 PPAK motif / PPAK motif / Titin, Z repeat / Titin Z / MyBP-C, tri-helix bundle domain / Tri-helix bundle domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain ...PPAK motif / PPAK motif / Titin, Z repeat / Titin Z / MyBP-C, tri-helix bundle domain / Tri-helix bundle domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase domain / Immunoglobulins / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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Model details | lowest energy, model 1 |
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データ登録者 | Yagawa, K. / Oguro, T. / Momose, T. / Kawano, S. / Sato, T. / Endo, T. |
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引用 | ジャーナル: Protein Sci. / 年: 2010 タイトル: Structural basis for unfolding pathway-dependent stability of proteins: Vectorial unfolding vs. global unfolding 著者: Yagawa, K. / Yamano, K. / Oguro, T. / Maeda, M. / Sato, T. / Momose, T. / Kawano, S. / Endo, T. |
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履歴 | 登録 | 2009年3月5日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2010年2月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2021年11月10日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_spectrometer ...database_2 / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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改定 1.3 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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