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Yorodumi- PDB-2q8u: CRYSTAL STRUCTURE OF MRE11 FROM THERMOTOGA MARITIMA MSB8 (TM1635)... -
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-Basic information
Entry | Database: PDB / ID: 2q8u | ||||||
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Title | CRYSTAL STRUCTURE OF MRE11 FROM THERMOTOGA MARITIMA MSB8 (TM1635) AT 2.20 A RESOLUTION | ||||||
Components | Exonuclease, putative | ||||||
Keywords | HYDROLASE / STRUCTURAL GENOMICS / JOINT CENTER FOR STRUCTURAL GENOMICS / JCSG / PROTEIN STRUCTURE INITIATIVE / PSI-2 | ||||||
Function / homology | Function and homology information DNA exonuclease activity / 3'-5' exonuclease activity / DNA endonuclease activity / double-strand break repair / DNA replication / DNA recombination / Hydrolases; Acting on ester bonds / DNA repair / DNA binding / metal ion binding Similarity search - Function | ||||||
Biological species | Thermotoga maritima MSB8 (bacteria) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution: 2.2 Å | ||||||
Authors | Joint Center for Structural Genomics (JCSG) | ||||||
Citation | Journal: J.Mol.Biol. / Year: 2010 Title: Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. Authors: Das, D. / Moiani, D. / Axelrod, H.L. / Miller, M.D. / McMullan, D. / Jin, K.K. / Abdubek, P. / Astakhova, T. / Burra, P. / Carlton, D. / Chiu, H.J. / Clayton, T. / Deller, M.C. / Duan, L. / ...Authors: Das, D. / Moiani, D. / Axelrod, H.L. / Miller, M.D. / McMullan, D. / Jin, K.K. / Abdubek, P. / Astakhova, T. / Burra, P. / Carlton, D. / Chiu, H.J. / Clayton, T. / Deller, M.C. / Duan, L. / Ernst, D. / Feuerhelm, J. / Grant, J.C. / Grzechnik, A. / Grzechnik, S.K. / Han, G.W. / Jaroszewski, L. / Klock, H.E. / Knuth, M.W. / Kozbial, P. / Krishna, S.S. / Kumar, A. / Marciano, D. / Morse, A.T. / Nigoghossian, E. / Okach, L. / Paulsen, J. / Reyes, R. / Rife, C.L. / Sefcovic, N. / Tien, H.J. / Trame, C.B. / van den Bedem, H. / Weekes, D. / Xu, Q. / Hodgson, K.O. / Wooley, J. / Elsliger, M.A. / Deacon, A.M. / Godzik, A. / Lesley, S.A. / Tainer, J.A. / Wilson, I.A. | ||||||
History |
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Remark 300 | BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAINS. ... BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAINS. SEE REMARK 350 FOR INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S). SIZE EXCLUSION CHROMATOGRAPHY SUGGESTS THE ASSIGNMENT OF A MONOMER AS THE SIGNIFICANT OLIGOMERIZATION STATE. | ||||||
Remark 999 | SEQUENCE THIS CONSTRUCT IS COMPRISED OF AMINO ACIDS 1-324 OF THE FULL-LENGTH PROTEIN (1-385) AND ... SEQUENCE THIS CONSTRUCT IS COMPRISED OF AMINO ACIDS 1-324 OF THE FULL-LENGTH PROTEIN (1-385) AND WAS EXPRESSED WITH A PURIFICATION TAG MGSDKIHHHHHH. DNA SEQUENCING INDICATES THAT RESIDUE 1 IS VALINE (NOT MET) IN THE CLONED CONSTRUCT. THE SEQUENCING RESULTS ARE CONSISTENT WITH THE ELECTRON DENSITY AND MASS SPECTROMETRY RESULTS FOR THE EXPRESSED PROTEIN. |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
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PDBx/mmCIF format | 2q8u.cif.gz | 138.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2q8u.ent.gz | 109.4 KB | Display | PDB format |
PDBx/mmJSON format | 2q8u.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2q8u_validation.pdf.gz | 440 KB | Display | wwPDB validaton report |
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Full document | 2q8u_full_validation.pdf.gz | 450 KB | Display | |
Data in XML | 2q8u_validation.xml.gz | 24.9 KB | Display | |
Data in CIF | 2q8u_validation.cif.gz | 35.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/q8/2q8u ftp://data.pdbj.org/pub/pdb/validation_reports/q8/2q8u | HTTPS FTP |
-Related structure data
Similar structure data | |
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Other databases |
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-Assembly
Deposited unit |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1 / Refine code: 4
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