登録情報 データベース : PDB / ID : 2q1l 構造の表示 ダウンロードとリンクタイトル Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors 要素3-hydroxy-3-methylglutaryl-coenzyme A reductase 詳細 キーワード OXIDOREDUCTASE / CHOLESTEROL BIOSYNTHESIS / HMG-COA / NADPH / STATIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
hydroxymethylglutaryl-CoA reductase (NADPH) / hydroxymethylglutaryl-CoA reductase (NADPH) activity / sterol biosynthetic process / GTPase regulator activity / coenzyme A binding / negative regulation of amyloid-beta clearance / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / coenzyme A metabolic process / isoprenoid biosynthetic process ... hydroxymethylglutaryl-CoA reductase (NADPH) / hydroxymethylglutaryl-CoA reductase (NADPH) activity / sterol biosynthetic process / GTPase regulator activity / coenzyme A binding / negative regulation of amyloid-beta clearance / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / coenzyme A metabolic process / isoprenoid biosynthetic process / peroxisomal membrane / cholesterol biosynthetic process / negative regulation of protein secretion / NADPH binding / regulation of ERK1 and ERK2 cascade / Activation of gene expression by SREBF (SREBP) / long-term synaptic potentiation / visual learning / negative regulation of protein catabolic process / PPARA activates gene expression / endoplasmic reticulum membrane / endoplasmic reticulum 類似検索 - 分子機能 HMGR, N-terminal domain / HMGR, N-terminal domain / Hydroxymethylglutaryl-CoA reductase, metazoan / Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type / Hydroxymethylglutaryl-CoA reductase, N-terminal / Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain / 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 / 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 / Hydroxymethylglutaryl-coenzyme A reductases signature 2. / Hydroxymethylglutaryl-coenzyme A reductases signature 1. ... HMGR, N-terminal domain / HMGR, N-terminal domain / Hydroxymethylglutaryl-CoA reductase, metazoan / Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type / Hydroxymethylglutaryl-CoA reductase, N-terminal / Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain / 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 / 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 / Hydroxymethylglutaryl-coenzyme A reductases signature 2. / Hydroxymethylglutaryl-coenzyme A reductases signature 1. / Hydroxymethylglutaryl-coenzyme A reductases signature 3. / Hydroxymethylglutaryl-CoA reductase, class I/II / Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site / Hydroxymethylglutaryl-coenzyme A reductase / Hydroxymethylglutaryl-coenzyme A reductases family profile. / Sterol-sensing domain of SREBP cleavage-activation / Sterol-sensing domain (SSD) profile. / Sterol-sensing domain / Alpha-Beta Plaits / Alpha-Beta Complex / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-882 / 3-hydroxy-3-methylglutaryl-coenzyme A reductase 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.05 Å 詳細データ登録者 Pavlovsky, A. / Pfefferkorn, J.A. / Harris, M.S. / Finzel, B.C. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2007タイトル : Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.著者: Pfefferkorn, J.A. / Song, Y. / Sun, K.L. / Miller, S.R. / Trivedi, B.K. / Choi, C. / Sorenson, R.J. / Bratton, L.D. / Unangst, P.C. / Larsen, S.D. / Poel, T.J. / Cheng, X.M. / Lee, C. / ... 著者 : Pfefferkorn, J.A. / Song, Y. / Sun, K.L. / Miller, S.R. / Trivedi, B.K. / Choi, C. / Sorenson, R.J. / Bratton, L.D. / Unangst, P.C. / Larsen, S.D. / Poel, T.J. / Cheng, X.M. / Lee, C. / Erasga, N. / Auerbach, B. / Askew, V. / Dillon, L. / Hanselman, J.C. / Lin, Z. / Lu, G. / Robertson, A. / Olsen, K. / Mertz, T. / Sekerke, C. / Pavlovsky, A. / Harris, M.S. / Bainbridge, G. / Caspers, N. / Chen, H. / Eberstadt, M. 履歴 登録 2007年5月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年7月17日 Provider : repository / タイプ : Initial release改定 1.1 2008年5月1日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2012年2月15日 Group : Database references改定 1.4 2017年10月18日 Group : Refinement description / カテゴリ : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version 改定 1.5 2021年10月20日 Group : Database references / Derived calculations / カテゴリ : database_2 / struct_ref_seq_dif / struct_siteItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.6 2024年2月21日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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