登録情報 データベース : PDB / ID : 2q15 構造の表示 ダウンロードとリンクタイトル Structure of BACE complexed to compound 3a 要素Beta-secretase 1 詳細 キーワード HYDROLASE / BACE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / hippocampal mossy fiber to CA3 synapse / multivesicular body / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / synaptic vesicle / late endosome / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.4 Å 詳細データ登録者 Sharff, A.J. 引用ジャーナル : J.Med.Chem. / 年 : 2007タイトル : 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.著者: Baxter, E.W. / Conway, K.A. / Kennis, L. / Bischoff, F. / Mercken, M.H. / Winter, H.L. / Reynolds, C.H. / Tounge, B.A. / Luo, C. / Scott, M.K. / Huang, Y. / Braeken, M. / Pieters, S.M. / ... 著者 : Baxter, E.W. / Conway, K.A. / Kennis, L. / Bischoff, F. / Mercken, M.H. / Winter, H.L. / Reynolds, C.H. / Tounge, B.A. / Luo, C. / Scott, M.K. / Huang, Y. / Braeken, M. / Pieters, S.M. / Berthelot, D.J. / Masure, S. / Bruinzeel, W.D. / Jordan, A.D. / Parker, M.H. / Boyd, R.E. / Qu, J. / Alexander, R.S. / Brenneman, D.E. / Reitz, A.B. 履歴 登録 2007年5月23日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年8月14日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2021年10月20日 Group : Database references / Derived calculationsカテゴリ : database_2 / struct_ref_seq_dif ... database_2 / struct_ref_seq_dif / struct_sheet / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_sheet.number_strands / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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