histone H2AK5 acetyltransferase activity / peptide crotonyltransferase activity / histone H2A acetyltransferase activity / positive regulation of mitotic sister chromatid segregation / positive regulation of protein acetylation / piccolo histone acetyltransferase complex / Sensing of DNA Double Strand Breaks / MSL complex / peptide butyryltransferase activity / histone H4K16 acetyltransferase activity ...histone H2AK5 acetyltransferase activity / peptide crotonyltransferase activity / histone H2A acetyltransferase activity / positive regulation of mitotic sister chromatid segregation / positive regulation of protein acetylation / piccolo histone acetyltransferase complex / Sensing of DNA Double Strand Breaks / MSL complex / peptide butyryltransferase activity / histone H4K16 acetyltransferase activity / lipid droplet disassembly / sperm DNA condensation / peptide 2-hydroxyisobutyryltransferase activity / positive regulation of attachment of mitotic spindle microtubules to kinetochore / peptidyl-lysine acetylation / positive regulation of triglyceride biosynthetic process / Swr1 complex / histone H4 acetyltransferase activity / regulation of double-strand break repair / Impaired BRCA2 binding to PALB2 / positive regulation of circadian rhythm / positive regulation of regulatory T cell differentiation / positive regulation of innate immune response / positive regulation of aggrephagy / Cardiogenesis / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / neural tube development / DNA repair-dependent chromatin remodeling / regulation of hematopoietic stem cell differentiation / Resolution of D-loop Structures through Holliday Junction Intermediates / negative regulation of interleukin-2 production / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / HDR through Single Strand Annealing (SSA) / peptide-lysine-N-acetyltransferase activity / Impaired BRCA2 binding to RAD51 / response to ionizing radiation / NuA4 histone acetyltransferase complex / mitotic spindle pole / establishment of mitotic spindle orientation / Presynaptic phase of homologous DNA pairing and strand exchange / acetyltransferase activity / positive regulation of double-strand break repair via homologous recombination / spermatid development / positive regulation of myoblast differentiation / negative regulation of double-strand break repair via homologous recombination / cellular response to glucose starvation / positive regulation of autophagy / histone acetyltransferase activity / histone acetyltransferase / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / neurogenesis / cellular response to estradiol stimulus / nucleotide-excision repair / cellular response to glucose stimulus / Nonhomologous End-Joining (NHEJ) / transcription coregulator activity / Formation of the beta-catenin:TCF transactivating complex / double-strand break repair via homologous recombination / G2/M DNA damage checkpoint / HDR through Homologous Recombination (HRR) / DNA Damage/Telomere Stress Induced Senescence / kinetochore / cellular senescence / nucleosome / double-strand break repair / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / site of double-strand break / HATs acetylate histones / Processing of DNA double-strand break ends / regulation of apoptotic process / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / Estrogen-dependent gene expression / Regulation of TP53 Activity through Phosphorylation / transcription regulator complex / transcription coactivator activity / regulation of cell cycle / intracellular membrane-bounded organelle / innate immune response / negative regulation of DNA-templated transcription / apoptotic process / DNA damage response / chromatin binding / chromatin / nucleolus / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 30 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.94 Å3/Da / Density % sol: 58.14 %
Crystal grow
Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6.6 Details: Purified HTATIP was complexed with acetylcoenzyme A (AcCoA) (Sigma) at 1:10 molar ratio of protein:AcCoA and crystallized using the hanging drop vapor diffusion method at 20 deg C by mixing ...Details: Purified HTATIP was complexed with acetylcoenzyme A (AcCoA) (Sigma) at 1:10 molar ratio of protein:AcCoA and crystallized using the hanging drop vapor diffusion method at 20 deg C by mixing 1 microliter of the protein solution with 1 microliter of the reservoir solution containing 16% PEG3350, 0.2 M ammonium acetate, 0.1 M Bis-Tris, pH 6.6., VAPOR DIFFUSION, HANGING DROP, temperature 293K
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