登録情報 | データベース: PDB / ID: 2oo4 |
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タイトル | Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 |
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要素 | Neurogenic locus notch homolog protein 2 |
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キーワード | CELL CYCLE / SIGNALING PROTEIN / alpha-beta-sandwich / SEA domain / LNR / Lin12 Notch Repeat / cysteine-rich / HD domain |
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機能・相同性 | 機能・相同性情報
cholangiocyte proliferation / proximal tubule development / regulation of osteoclast development / intrahepatic bile duct development / glomerular capillary formation / ciliary body morphogenesis / podocyte development / Defective LFNG causes SCDO3 / morphogenesis of an epithelial sheet / marginal zone B cell differentiation ...cholangiocyte proliferation / proximal tubule development / regulation of osteoclast development / intrahepatic bile duct development / glomerular capillary formation / ciliary body morphogenesis / podocyte development / Defective LFNG causes SCDO3 / morphogenesis of an epithelial sheet / marginal zone B cell differentiation / Pre-NOTCH Processing in the Endoplasmic Reticulum / atrioventricular node development / cellular response to tumor cell / positive regulation of keratinocyte proliferation / atrial septum morphogenesis / positive regulation of smooth muscle cell differentiation / hepatocyte proliferation / left/right axis specification / NOTCH2 intracellular domain regulates transcription / Pre-NOTCH Processing in Golgi / placenta blood vessel development / myeloid dendritic cell differentiation / pulmonary valve morphogenesis / cell fate determination / bone remodeling / positive regulation of BMP signaling pathway / positive regulation of osteoclast differentiation / inflammatory response to antigenic stimulus / positive regulation of Ras protein signal transduction / Notch binding / embryonic limb morphogenesis / NOTCH4 Intracellular Domain Regulates Transcription / Notch-HLH transcription pathway / heart looping / humoral immune response / hemopoiesis / NF-kappaB binding / cis-regulatory region sequence-specific DNA binding / BMP signaling pathway / Notch signaling pathway / NOTCH2 Activation and Transmission of Signal to the Nucleus / animal organ morphogenesis / axon guidance / wound healing / multicellular organism growth / Pre-NOTCH Transcription and Translation / cilium / positive regulation of miRNA transcription / nervous system development / signaling receptor activity / DNA-binding transcription activator activity, RNA polymerase II-specific / in utero embryonic development / positive regulation of ERK1 and ERK2 cascade / receptor complex / intracellular signal transduction / defense response to bacterium / positive regulation of apoptotic process / Golgi membrane / negative regulation of gene expression / apoptotic process / calcium ion binding / endoplasmic reticulum membrane / negative regulation of apoptotic process / enzyme binding / cell surface / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular region / nucleoplasm / membrane / nucleus / plasma membrane類似検索 - 分子機能 Neurogenic locus notch homolog protein 2 / GMP Synthetase; Chain A, domain 3 - #320 / Alpha-Beta Plaits - #3310 / Notch, C-terminal / Domain of unknown function / Notch / Notch, NOD domain / Notch, NODP domain / NOTCH protein / NOTCH protein ...Neurogenic locus notch homolog protein 2 / GMP Synthetase; Chain A, domain 3 - #320 / Alpha-Beta Plaits - #3310 / Notch, C-terminal / Domain of unknown function / Notch / Notch, NOD domain / Notch, NODP domain / NOTCH protein / NOTCH protein / NOD / NODP / Notch-like domain superfamily / LNR (Lin-12/Notch) repeat profile. / LNR domain / Notch domain / Domain found in Notch and Lin-12 / EGF-like, conserved site / Human growth factor-like EGF / : / Calcium-binding EGF domain / GMP Synthetase; Chain A, domain 3 / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / Ankyrin repeat / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 多重同系置換・異常分散 / 解像度: 2.003 Å |
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データ登録者 | Gordon, W.R. / Vardar-Ulu, D. / Histen, G. / Sanchez-Irizarry, C. / Aster, J.C. / Blacklow, S.C. |
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2007 タイトル: Structural basis for autoinhibition of Notch 著者: Gordon, W.R. / Vardar-Ulu, D. / Histen, G. / Sanchez-Irizarry, C. / Aster, J.C. / Blacklow, S.C. |
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履歴 | 登録 | 2007年1月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年4月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.3 | 2015年4月8日 | Group: Database references |
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改定 1.4 | 2017年10月18日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
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改定 1.5 | 2023年12月27日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ncs_dom_lim / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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