登録情報 | データベース: PDB / ID: 2oaz |
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タイトル | Human Methionine Aminopeptidase-2 Complexed with SB-587094 |
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要素 | human Methionine Amino Peptidase 2 |
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キーワード | HYDROLASE / MetAP2 / Methionine / Amino Peptidase |
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機能・相同性 | 機能・相同性情報
N-terminal protein amino acid modification / peptidyl-methionine modification / initiator methionyl aminopeptidase activity / methionyl aminopeptidase / metalloexopeptidase activity / metalloaminopeptidase activity / aminopeptidase activity / protein processing / Inactivation, recovery and regulation of the phototransduction cascade / RNA binding ...N-terminal protein amino acid modification / peptidyl-methionine modification / initiator methionyl aminopeptidase activity / methionyl aminopeptidase / metalloexopeptidase activity / metalloaminopeptidase activity / aminopeptidase activity / protein processing / Inactivation, recovery and regulation of the phototransduction cascade / RNA binding / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Peptidase M24A, methionine aminopeptidase, subfamily 2 / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Peptidase M24, methionine aminopeptidase / Creatine Amidinohydrolase / Creatinase/methionine aminopeptidase superfamily / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain ...Peptidase M24A, methionine aminopeptidase, subfamily 2 / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Peptidase M24, methionine aminopeptidase / Creatine Amidinohydrolase / Creatinase/methionine aminopeptidase superfamily / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Marino Jr., J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, D. ...Marino Jr., J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, D. / Schulz, C. / Smith, W.W. / Tew, D.G. / Tomazek Jr., T.A. / Veber, D.F. / Xiong, W.C. / Yamamoto, Y. / Yamashita, K. / Yang, G. / Thompson, S.K. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2007 タイトル: Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. 著者: Marino, J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R.B. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, M.D. / Schulz, C. / Smith, W.W. / Tew, D.G. / ...著者: Marino, J.P. / Fisher, P.W. / Hofmann, G.A. / Kirkpatrick, R.B. / Janson, C.A. / Johnson, R.K. / Ma, C. / Mattern, M. / Meek, T.D. / Ryan, M.D. / Schulz, C. / Smith, W.W. / Tew, D.G. / Tomazek, T.A. / Veber, D.F. / Xiong, W.C. / Yamamoto, Y. / Yamashita, K. / Yang, G. / Thompson, S.K. |
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履歴 | 登録 | 2006年12月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年6月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年1月14日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2023年12月27日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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