- PDB-2mxb: Structure of the transmembrane domain of the mouse erythropoietin... -
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Basic information
Entry
Database: PDB / ID: 2mxb
Title
Structure of the transmembrane domain of the mouse erythropoietin receptor
Components
Erythropoietin receptor
Keywords
MEMBRANE PROTEIN
Function / homology
Function and homology information
: / erythropoietin receptor activity / Erythropoietin activates RAS / visceral serous pericardium development / vasculogenesis involved in coronary vascular morphogenesis / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / negative regulation of nitric oxide biosynthetic process / cardiac muscle tissue morphogenesis / ventricular cardiac muscle tissue morphogenesis / decidualization ...: / erythropoietin receptor activity / Erythropoietin activates RAS / visceral serous pericardium development / vasculogenesis involved in coronary vascular morphogenesis / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / negative regulation of nitric oxide biosynthetic process / cardiac muscle tissue morphogenesis / ventricular cardiac muscle tissue morphogenesis / decidualization / heart morphogenesis / viral process / brain development / positive regulation of neuron projection development / heart development / positive regulation of cytosolic calcium ion concentration / negative regulation of neuron apoptotic process / positive regulation of ERK1 and ERK2 cascade / membrane => GO:0016020 / nuclear speck / external side of plasma membrane / positive regulation of cell population proliferation / signal transduction / extracellular region / identical protein binding / plasma membrane / cytoplasm Similarity search - Function
Erythropoietin receptor / Long hematopoietin receptor, single chain, conserved site / Long hematopoietin receptor, single chain family signature. / Growth hormone/erythropoietin receptor, ligand binding / Erythropoietin receptor, ligand binding / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin-like fold Similarity search - Domain/homology
Method: simulated annealing / Software ordinal: 1 Details: SIMULATED ANNEALING WAS STARTED WITH 3500 AND COOL DOWN TO 100 K WITH 15,000 STEPS. STRUCTURE WAS ENERGY MINIMIZED WITH POWELL ENERGY MINIMIZATION.
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 50 / Conformers submitted total number: 20
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