- PDB-2mvw: Solution structure of the TRIM19 B-box1 (B1) of human promyelocyt... -
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基本情報
登録情報
データベース: PDB / ID: 2mvw
タイトル
Solution structure of the TRIM19 B-box1 (B1) of human promyelocytic leukemia (PML)
要素
Protein PML
キーワード
METAL BINDING PROTEIN / PML / B box / TRIM19 / E3 ligase
機能・相同性
機能・相同性情報
regulation of calcium ion transport into cytosol / ubiquitin-like protein ligase activity / negative regulation of translation in response to oxidative stress / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / positive regulation of apoptotic process involved in mammary gland involution / : ...regulation of calcium ion transport into cytosol / ubiquitin-like protein ligase activity / negative regulation of translation in response to oxidative stress / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / positive regulation of apoptotic process involved in mammary gland involution / : / fibroblast migration / endoplasmic reticulum calcium ion homeostasis / SMAD protein signal transduction / positive regulation of telomere maintenance / myeloid cell differentiation / regulation of double-strand break repair / maintenance of protein location in nucleus / protein-containing complex localization / 転移酵素; アシル基を移すもの; アミノアシル基を移すもの / positive regulation of extrinsic apoptotic signaling pathway / oncogene-induced cell senescence / Regulation of RUNX1 Expression and Activity / branching involved in mammary gland duct morphogenesis / SUMO transferase activity / negative regulation of interleukin-1 beta production / intrinsic apoptotic signaling pathway in response to oxidative stress / cobalt ion binding / SUMOylation of ubiquitinylation proteins / entrainment of circadian clock by photoperiod / SMAD binding / negative regulation of telomere maintenance via telomerase / positive regulation of signal transduction by p53 class mediator / protein sumoylation / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / negative regulation of mitotic cell cycle / cell fate commitment / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / protein targeting / cellular response to interleukin-4 / regulation of cell adhesion / retinoic acid receptor signaling pathway / positive regulation of defense response to virus by host / negative regulation of ubiquitin-dependent protein catabolic process / SUMOylation of DNA damage response and repair proteins / response to UV / extrinsic apoptotic signaling pathway / Regulation of TP53 Activity through Acetylation / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / Regulation of PTEN localization / negative regulation of angiogenesis / transforming growth factor beta receptor signaling pathway / response to cytokine / response to gamma radiation / cellular response to leukemia inhibitory factor / circadian regulation of gene expression / regulation of circadian rhythm / PML body / negative regulation of cell growth / nuclear matrix / HCMV Early Events / Transcriptional regulation of granulopoiesis / intrinsic apoptotic signaling pathway in response to DNA damage / protein import into nucleus / Interferon gamma signaling / cellular senescence / positive regulation of fibroblast proliferation / early endosome membrane / protein-containing complex assembly / nuclear membrane / proteasome-mediated ubiquitin-dependent protein catabolic process / molecular adaptor activity / chromosome, telomeric region / transcription coactivator activity / response to hypoxia / regulation of cell cycle / protein stabilization / chromatin remodeling / protein heterodimerization activity / negative regulation of cell population proliferation / innate immune response / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / endoplasmic reticulum membrane / regulation of DNA-templated transcription / nucleolus / apoptotic process / protein homodimerization activity / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能
NOE constraints total: 1391 / NOE long range total count: 393 / NOE medium range total count: 213 / Protein phi angle constraints total count: 42 / Protein psi angle constraints total count: 42
代表構造
選択基準: lowest energy
NMRアンサンブル
コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 20