- PDB-2ms7: High-resolution solid-state NMR structure of the helical signal t... -
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Basic information
Entry
Database: PDB / ID: 2ms7
Title
High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD
Components
Mitochondrial antiviral-signaling protein
Keywords
PROTEIN BINDING / MAVS CARD filament
Function / homology
Function and homology information
positive regulation of IP-10 production / regulation of peroxisome organization / RIG-I binding / positive regulation of chemokine (C-C motif) ligand 5 production / positive regulation of myeloid dendritic cell cytokine production / CARD domain binding / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / protein localization to mitochondrion / positive regulation of response to cytokine stimulus / positive regulation of type I interferon-mediated signaling pathway ...positive regulation of IP-10 production / regulation of peroxisome organization / RIG-I binding / positive regulation of chemokine (C-C motif) ligand 5 production / positive regulation of myeloid dendritic cell cytokine production / CARD domain binding / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / protein localization to mitochondrion / positive regulation of response to cytokine stimulus / positive regulation of type I interferon-mediated signaling pathway / peroxisomal membrane / TRAF6 mediated IRF7 activation / negative regulation of type I interferon-mediated signaling pathway / positive regulation of NLRP3 inflammasome complex assembly / cytoplasmic pattern recognition receptor signaling pathway / negative regulation of viral genome replication / type I interferon-mediated signaling pathway / cellular response to exogenous dsRNA / TRAF6 mediated NF-kB activation / antiviral innate immune response / positive regulation of type I interferon production / positive regulation of interferon-alpha production / signaling adaptor activity / ubiquitin ligase complex / positive regulation of defense response to virus by host / activation of innate immune response / positive regulation of interferon-beta production / molecular condensate scaffold activity / positive regulation of interleukin-8 production / Negative regulators of DDX58/IFIH1 signaling / mitochondrial membrane / DDX58/IFIH1-mediated induction of interferon-alpha/beta / PKR-mediated signaling / Evasion by RSV of host interferon responses / positive regulation of DNA-binding transcription factor activity / positive regulation of protein import into nucleus / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / Ovarian tumor domain proteases / TRAF3-dependent IRF activation pathway / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / mitochondrial outer membrane / molecular adaptor activity / defense response to bacterium / positive regulation of protein phosphorylation / innate immune response / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / signal transduction / positive regulation of transcription by RNA polymerase II / mitochondrion / identical protein binding Similarity search - Function
A: Mitochondrial antiviral-signaling protein B: Mitochondrial antiviral-signaling protein C: Mitochondrial antiviral-signaling protein D: Mitochondrial antiviral-signaling protein E: Mitochondrial antiviral-signaling protein F: Mitochondrial antiviral-signaling protein G: Mitochondrial antiviral-signaling protein H: Mitochondrial antiviral-signaling protein I: Mitochondrial antiviral-signaling protein J: Mitochondrial antiviral-signaling protein K: Mitochondrial antiviral-signaling protein L: Mitochondrial antiviral-signaling protein M: Mitochondrial antiviral-signaling protein N: Mitochondrial antiviral-signaling protein O: Mitochondrial antiviral-signaling protein P: Mitochondrial antiviral-signaling protein Q: Mitochondrial antiviral-signaling protein R: Mitochondrial antiviral-signaling protein S: Mitochondrial antiviral-signaling protein T: Mitochondrial antiviral-signaling protein U: Mitochondrial antiviral-signaling protein
Type: Bruker Avance / Manufacturer: Bruker / Model: AVANCE / Field strength: 600 MHz
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Processing
NMR software
Name
Version
Developer
Classification
CcpNmr
CCPN
dataanalysis
CcpNmr
CCPN
chemicalshiftassignment
ARIA
2.3.2
Linge, O'DonoghueandNilges
structuresolution
ARIA
2.3.2
Linge, O'DonoghueandNilges
dataanalysis
CNS
1.2
Brunger, Adams, Clore, Gros, NilgesandRead
structuresolution
CNS
1.2
Brunger, Adams, Clore, Gros, NilgesandRead
geometryoptimization
TALOS
Cornilescu, DelaglioandBax
dataanalysis
TopSpin
BrukerBiospin
collection
TopSpin
BrukerBiospin
processing
ARIA/CNS
refinement
Refinement
Method: simulated annealing / Software ordinal: 1 Details: Simulated annealing with helical symmetry constrained by strict NCS.
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 500 / Conformers submitted total number: 15 / Representative conformer: 1
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