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- PDB-2mrb: THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD-7 METALLOTHIONEIN-... -

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Entry
Database: PDB / ID: 2mrb
TitleTHREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD-7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE
ComponentsCD7 METALLOTHIONEIN-2A
KeywordsMETALLOTHIONEIN
Function / homology
Function and homology information


negative regulation of growth / detoxification of copper ion / intracellular zinc ion homeostasis / cellular response to zinc ion / cellular response to copper ion / cellular response to cadmium ion / zinc ion binding / nucleus / cytoplasm
Similarity search - Function
Metallothionein, vertebrate / Metallothionein, vertebrate, metal binding site / Metallothionein domain superfamily, vertebrate / Metallothionein / Vertebrate metallothioneins signature. / Metallothionein domain superfamily
Similarity search - Domain/homology
: / Metallothionein-2A
Similarity search - Component
Biological speciesOryctolagus cuniculus (rabbit)
MethodSOLUTION NMR
AuthorsBraun, W. / Arseniev, A. / Schultze, P. / Woergoetter, E. / Wagner, G. / Vasak, M. / Kaegi, J.H.R. / Wuthrich, K.
Citation
Journal: J.Mol.Biol. / Year: 1988
Title: Three-dimensional structure of rabbit liver [Cd7]metallothionein-2a in aqueous solution determined by nuclear magnetic resonance.
Authors: Arseniev, A. / Schultze, P. / Worgotter, E. / Braun, W. / Wagner, G. / Vasak, M. / Kagi, J.H. / Wuthrich, K.
#1: Journal: J.Mol.Biol. / Year: 1986
Title: Nuclear Magnetic Resonance Identification of "Half-Turn" and 310-Helix Secondary Structure in Rabbit Liver Metallothionein-2
Authors: Wagner, G. / Neuhaus, D. / Woergoetter, E. / Vasak, M. / Kaegi, J.H.R. / Wuthrich, K.
#2: Journal: J.Mol.Biol. / Year: 1986
Title: Polypeptide Fold in the Two Metal Clusters of Metallothionein-2 by Nuclear Magnetic Resonance in Solution
Authors: Braun, W. / Wagner, G. / Woergoetter, E. / Vasak, M. / Kaegi, J.H.R. / Wuthrich, K.
#3: Journal: Eur.J.Biochem. / Year: 1986
Title: Sequence-Specific 1H-NMR Assignments in Rabbit-Liver Metallothionein-2
Authors: Wagner, G. / Neuhaus, D. / Woergoetter, E. / Vasak, M. / Kaegi, J.H.R. / Wuthrich, K.
#4: Journal: Eur.J.Biochem. / Year: 1985
Title: Systematic Application of High-Resolution,Phase-Sensitive Two-Dimensional 1H-NMR Techniques for the Identification of the Amino-Acid-Proton Spin Systems in Proteins
Authors: Neuhaus, D. / Wagner, G. / Vasak, M. / Kaegi, J.H.R. / Wuthrich, K.
#5: Journal: J.Am.Chem.Soc. / Year: 1985
Title: Polypeptide-Metal Cluster Connectivies in Metallo Thionein 2 by Novel 1H-113Cd Heteronuclear Two-Dimensional NMR Experiments
Authors: Frey, M.H. / Wagner, G. / Vasak, M. / Sorensen, O.W. / Neuhaus, D. / Woergoetter, E. / Kaegi, J.H.R. / Ernst, R.R. / Wuthrich, K.
History
DepositionMay 14, 1990Processing site: BNL
Revision 1.0Apr 15, 1991Provider: repository / Type: Initial release
Revision 1.1Mar 3, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: CD7 METALLOTHIONEIN-2A
hetero molecules


Theoretical massNumber of molelcules
Total (without water)3,4224
Polymers3,0851
Non-polymers3373
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Atom site foot note1: THE THREE CADMIUM ATOMS AND THE NINE SULPHUR ATOMS TO WHICH THEY ARE BONDED FORM A CD3 S9 METAL CLUSTER.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein/peptide CD7 METALLOTHIONEIN-2A


Mass: 3084.595 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Oryctolagus cuniculus (rabbit) / References: UniProt: P18055
#2: Chemical ChemComp-CD / CADMIUM ION


Mass: 112.411 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Cd

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

NMR softwareName: DISMAN / Developer: BRAUN,GO / Classification: refinement
NMR ensembleConformers submitted total number: 1

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