登録情報 データベース : PDB / ID : 2mjv 構造の表示 ダウンロードとリンクタイトル Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide 要素Bromodomain-containing protein 4 Twist-related protein 1 詳細キーワード TRANSCRIPTION / tumorigenesis機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
embryonic camera-type eye formation / cell proliferation involved in heart valve development / positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation / negative regulation of peroxisome proliferator activated receptor signaling pathway / cranial suture morphogenesis / negative regulation of double-strand break repair / negative regulation of skeletal muscle tissue development / positive regulation of DNA-templated transcription initiation / negative regulation of striated muscle tissue development / negative regulation of macrophage cytokine production ... embryonic camera-type eye formation / cell proliferation involved in heart valve development / positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation / negative regulation of peroxisome proliferator activated receptor signaling pathway / cranial suture morphogenesis / negative regulation of double-strand break repair / negative regulation of skeletal muscle tissue development / positive regulation of DNA-templated transcription initiation / negative regulation of striated muscle tissue development / negative regulation of macrophage cytokine production / cardiac neural crest cell migration involved in outflow tract morphogenesis / bHLH transcription factor binding / mitral valve morphogenesis / developmental process / positive regulation of transcription regulatory region DNA binding / Transcriptional regulation by RUNX2 / positive regulation of fatty acid beta-oxidation / eyelid development in camera-type eye / E-box binding / regulation of bone mineralization / embryonic cranial skeleton morphogenesis / positive regulation of monocyte chemotactic protein-1 production / embryonic forelimb morphogenesis / aortic valve morphogenesis / outer ear morphogenesis / embryonic hindlimb morphogenesis / positive regulation of cell motility / muscle organ development / endocardial cushion morphogenesis / DNA-binding transcription repressor activity / embryonic digit morphogenesis / negative regulation of osteoblast differentiation / roof of mouth development / negative regulation of cellular senescence / negative regulation of DNA damage response, signal transduction by p53 class mediator / negative regulation of tumor necrosis factor production / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cis-regulatory region sequence-specific DNA binding / ossification / Nuclear events stimulated by ALK signaling in cancer / positive regulation of epithelial to mesenchymal transition / positive regulation of epithelial cell proliferation / energy homeostasis / negative regulation of miRNA transcription / transcription coregulator binding / neural tube closure / RNA polymerase II transcription regulatory region sequence-specific DNA binding / neuron migration / cellular response to growth factor stimulus / histone deacetylase binding / positive regulation of interleukin-6 production / osteoblast differentiation / rhythmic process / positive regulation of angiogenesis / Regulation of RUNX2 expression and activity / positive regulation of tumor necrosis factor production / cellular response to hypoxia / DNA-binding transcription factor binding / Interleukin-4 and Interleukin-13 signaling / toxin activity / in utero embryonic development / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of cell migration / protein domain specific binding / negative regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of gene expression / chromatin / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / nucleoplasm / nucleus 類似検索 - 分子機能 : / : / Helix-loop-helix DNA-binding domain / Amanitin/phalloidin toxin / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Bromodomain-like / Histone Acetyltransferase; Chain A ... : / : / Helix-loop-helix DNA-binding domain / Amanitin/phalloidin toxin / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Alpha-amanitin proprotein 1 / Twist-related protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing , DGSA-distance geometry simulated annealing 詳細Model details lowest energy, model1 データ登録者 Zeng, L. / Zhou, M. 引用ジャーナル : Cancer Cell / 年 : 2014タイトル : Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.著者 : Shi, J. / Wang, Y. / Zeng, L. / Wu, Y. / Deng, J. / Zhang, Q. / Lin, Y. / Li, J. / Kang, T. / Tao, M. / Rusinova, E. / Zhang, G. / Wang, C. / Zhu, H. / Yao, J. / Zeng, Y.X. / Evers, B.M. / Zhou, M.M. / Zhou, B.P. 履歴 登録 2014年1月16日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2014年3月19日 Provider : repository / タイプ : Initial release改定 2.0 2023年11月15日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations カテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_conn Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag