登録情報 データベース : PDB / ID : 2mfq 構造の表示 ダウンロードとリンクタイトル NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB 要素BDNF/NT-3 growth factors receptor Fibroblast growth factor receptor substrate 2 詳細キーワード TRANSFERASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
lens placode formation involved in camera-type eye formation / brain-derived neurotrophic factor receptor activity / trans-synaptic signaling by neuropeptide, modulating synaptic transmission / BDNF activates NTRK2 (TRKB) signaling / NTF4 activates NTRK2 (TRKB) signaling / NTF3 activates NTRK2 (TRKB) signaling / brain-derived neurotrophic factor receptor signaling pathway / Activated NTRK2 signals through PLCG1 / retinal rod cell development / peripheral nervous system neuron development ... lens placode formation involved in camera-type eye formation / brain-derived neurotrophic factor receptor activity / trans-synaptic signaling by neuropeptide, modulating synaptic transmission / BDNF activates NTRK2 (TRKB) signaling / NTF4 activates NTRK2 (TRKB) signaling / NTF3 activates NTRK2 (TRKB) signaling / brain-derived neurotrophic factor receptor signaling pathway / Activated NTRK2 signals through PLCG1 / retinal rod cell development / peripheral nervous system neuron development / cell surface receptor protein tyrosine phosphatase signaling pathway / brain-derived neurotrophic factor binding / negative regulation of cardiac muscle cell differentiation / lens fiber cell development / trans-synaptic signaling by BDNF, modulating synaptic transmission / mechanoreceptor differentiation / anterior/posterior axis specification, embryo / neurotrophin binding / Activated NTRK2 signals through CDK5 / NTRK2 activates RAC1 / Activated NTRK2 signals through FYN / phosphatase activator activity / fibroblast growth factor receptor binding / NGF-independant TRKA activation / myelination in peripheral nervous system / organ induction / neurotrophin TRKA receptor binding / Activated NTRK2 signals through PI3K / regulation of epithelial cell proliferation / transmembrane receptor protein tyrosine kinase adaptor activity / glutamate secretion / gastrulation with mouth forming second / feeding behavior / neuronal action potential propagation / positive regulation of synapse assembly / RND1 GTPase cycle / RND2 GTPase cycle / ventricular septum development / positive regulation of axonogenesis / Signaling by ALK / Frs2-mediated activation / PI-3K cascade:FGFR3 / regulation of GTPase activity / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / central nervous system neuron development / PI-3K cascade:FGFR1 / oligodendrocyte differentiation / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of amyloid-beta formation / negative regulation of anoikis / RET signaling / Activated NTRK2 signals through RAS / PI3K Cascade / neuroblast proliferation / fibroblast growth factor receptor signaling pathway / vasculogenesis / Activated NTRK2 signals through FRS2 and FRS3 / endomembrane system / Signaling by FGFR4 in disease / axon terminus / FRS-mediated FGFR3 signaling / forebrain development / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to brain-derived neurotrophic factor stimulus / Signaling by FGFR2 in disease / Signaling by FGFR1 in disease / regulation of ERK1 and ERK2 cascade / learning / long-term synaptic potentiation / Negative regulation of FGFR3 signaling / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / adherens junction / Negative regulation of FGFR1 signaling / cellular response to amino acid stimulus / neuron migration / neuron differentiation / terminal bouton / receptor protein-tyrosine kinase / cerebral cortex development / positive regulation of neuron projection development / circadian rhythm / Constitutive Signaling by Aberrant PI3K in Cancer / cell-cell junction / Signaling by ALK fusions and activated point mutants / PIP3 activates AKT signaling / positive regulation of peptidyl-serine phosphorylation / early endosome membrane / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / regulation of apoptotic process / protease binding / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade 類似検索 - 分子機能 FRS2, PTB domain / BDNF/NT-3 growth factors receptor NTRK2 / Phosphotyrosine-binding domain (IRS1-like) / IRS-type PTB domain profile. / IRS-type PTB domain / PTB domain (IRS-1 type) / Growth factor receptor NTRK / Growth factor receptor NTRK, leucine rich repeat C-terminal / Leucine rich repeat C-terminal motif / Phosphotyrosine-binding domain ... FRS2, PTB domain / BDNF/NT-3 growth factors receptor NTRK2 / Phosphotyrosine-binding domain (IRS1-like) / IRS-type PTB domain profile. / IRS-type PTB domain / PTB domain (IRS-1 type) / Growth factor receptor NTRK / Growth factor receptor NTRK, leucine rich repeat C-terminal / Leucine rich repeat C-terminal motif / Phosphotyrosine-binding domain / Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / Leucine rich repeat / Immunoglobulin I-set / Immunoglobulin I-set domain / Leucine-rich repeat / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Leucine-rich repeat domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Roll / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 BDNF/NT-3 growth factors receptor / Fibroblast growth factor receptor substrate 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細Model details lowest energy, model1 データ登録者 Zeng, L. / Zhou, M. 引用ジャーナル : Proteins / 年 : 2014タイトル : Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.著者 : Zeng, L. / Kuti, M. / Mujtaba, S. / Zhou, M.M. 履歴 登録 2013年10月18日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2014年3月5日 Provider : repository / タイプ : Initial release改定 1.1 2014年6月25日 Group : Database references
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