Entry Database : PDB / ID : 2m3m Structure visualization Downloads & linksTitle Solution structure of a complex consisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151 ComponentsDisks large homolog 1 Protein E6 DetailsKeywords ONCOPROTEIN/CELL ADHESION / Papillomavirus E6 Proteins / HPV / Oncoprotein E6 / E6 / Viral / Oncogene Proteins / PDZ Domain / hDlgPDZ2 / hDlg / hDlg1 / SAP-97 / Dlg / ONCOPROTEIN - CELL ADHESION protein complex / ONCOPROTEIN-CELL ADHESION complexFunction / homology Function and homology informationFunction Domain/homology Component
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade ... regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade / guanylate kinase activity / cortical microtubule organization / regulation of sodium ion transmembrane transport / embryonic skeletal system morphogenesis / astral microtubule organization / structural constituent of postsynaptic density / NrCAM interactions / lateral loop / reproductive structure development / immunological synapse formation / myelin sheath abaxonal region / peristalsis / cell projection membrane / Synaptic adhesion-like molecules / smooth muscle tissue development / bicellular tight junction assembly / positive regulation of potassium ion transport / node of Ranvier / regulation of ventricular cardiac muscle cell action potential / regulation of proteolysis / protein-containing complex localization / Trafficking of AMPA receptors / Assembly and cell surface presentation of NMDA receptors / establishment or maintenance of epithelial cell apical/basal polarity / amyloid precursor protein metabolic process / neurotransmitter receptor localization to postsynaptic specialization membrane / endothelial cell proliferation / lens development in camera-type eye / Activation of Ca-permeable Kainate Receptor / regulation of myelination / cortical actin cytoskeleton organization / branching involved in ureteric bud morphogenesis / establishment or maintenance of cell polarity / negative regulation of G1/S transition of mitotic cell cycle / positive regulation of actin filament polymerization / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / receptor clustering / phosphoprotein phosphatase activity / Long-term potentiation / immunological synapse / intercalated disc / basement membrane / lateral plasma membrane / potassium channel regulator activity / bicellular tight junction / phosphatase binding / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / T cell proliferation / negative regulation of T cell proliferation / cytoskeletal protein binding / Ras activation upon Ca2+ influx through NMDA receptor / actin filament polymerization / phosphatidylinositol 3-kinase/protein kinase B signal transduction / synaptic membrane / protein localization to plasma membrane / PDZ domain binding / regulation of membrane potential / positive regulation of protein localization to plasma membrane / actin filament organization / adherens junction / postsynaptic density membrane / neuromuscular junction / cytoplasmic side of plasma membrane / negative regulation of ERK1 and ERK2 cascade / sarcolemma / kinase binding / cell-cell adhesion / negative regulation of epithelial cell proliferation / cell-cell junction / cell junction / regulation of cell shape / RAF/MAP kinase cascade / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity / chemical synaptic transmission / basolateral plasma membrane / symbiont-mediated perturbation of host ubiquitin-like protein modification / microtubule / transmembrane transporter binding / host cell cytoplasm / molecular adaptor activity / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / cadherin binding / neuron projection / membrane raft / apical plasma membrane / virus-mediated perturbation of host defense response / DNA-templated transcription / glutamatergic synapse / host cell nucleus Similarity search - Function L27-1 / L27_1 / E6 early regulatory protein / E6 superfamily / Early Protein (E6) / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK ... L27-1 / L27_1 / E6 early regulatory protein / E6 superfamily / Early Protein (E6) / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human) Human papillomavirusMethod SOLUTION NMR / DGSA-distance geometry simulated annealing , molecular dynamics DetailsModel details lowest energy, model1 Authors Mischo, A. / Ohlenschlager, O. / Gorlach, M. CitationJournal : Plos One / Year : 2013Title : Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain.Authors : Mischo, A. / Ohlenschlager, O. / Hortschansky, P. / Ramachandran, R. / Gorlach, M. History Deposition Jan 22, 2013 Deposition site : BMRB / Processing site : RCSBRevision 1.0 May 15, 2013 Provider : repository / Type : Initial releaseRevision 2.0 Dec 25, 2019 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Polymer sequence Category : entity_poly / pdbx_nmr_software ... entity_poly / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_mod_residue / struct_conn / struct_ref_seq_dif Item : _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_nmr_software.name ... _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _pdbx_struct_mod_residue.parent_comp_id / _struct_conn.pdbx_leaving_atom_flag Revision 2.1 Jun 14, 2023 Group : Database references / Other / Category : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data
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