登録情報 | データベース: PDB / ID: 2lqh |
---|
タイトル | NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation) |
---|
要素 | - CREB-binding protein
- Forkhead box O3
|
---|
キーワード | TRANSCRIPTION / promiscuous binding / intrinsic disorder |
---|
機能・相同性 | 機能・相同性情報
positive regulation of muscle atrophy / initiation of primordial ovarian follicle growth / positive regulation of hydrogen peroxide-mediated programmed cell death / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / Attenuation phase / RNA polymerase II transcription repressor complex / Regulation of gene expression by Hypoxia-inducible Factor ...positive regulation of muscle atrophy / initiation of primordial ovarian follicle growth / positive regulation of hydrogen peroxide-mediated programmed cell death / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / Attenuation phase / RNA polymerase II transcription repressor complex / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / mitochondrial transcription factor activity / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / Notch-HLH transcription pathway / RUNX3 regulates BCL2L11 (BIM) transcription / cellular response to corticosterone stimulus / FOXO-mediated transcription of cell cycle genes / AKT phosphorylates targets in the nucleus / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / negative regulation of viral process / Regulation of lipid metabolism by PPARalpha / Cytoprotection by HMOX1 / ovulation from ovarian follicle / response to water-immersion restraint stress / mitochondrial transcription / neuronal stem cell population maintenance / regulation of neural precursor cell proliferation / CD209 (DC-SIGN) signaling / Estrogen-dependent gene expression / peptide lactyltransferase (CoA-dependent) activity / outer kinetochore / response to fatty acid / negative regulation of interferon-beta production / positive regulation of endothelial cell apoptotic process / positive regulation of regulatory T cell differentiation / Signaling by NODAL / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / brain morphogenesis / MRF binding / peroxisome proliferator activated receptor binding / face morphogenesis / Regulation of FOXO transcriptional activity by acetylation / oocyte maturation / negative regulation of transcription by RNA polymerase I / positive regulation of reactive oxygen species biosynthetic process / peptide-lysine-N-acetyltransferase activity / FOXO-mediated transcription of cell death genes / antral ovarian follicle growth / cellular response to hepatocyte growth factor stimulus / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / positive regulation of dendritic spine development / response to dexamethasone / SMAD binding / Constitutive Signaling by AKT1 E17K in Cancer / response to starvation / behavioral response to cocaine / acetyltransferase activity / TFIIB-class transcription factor binding / Regulation of localization of FOXO transcription factors / positive regulation of double-strand break repair via homologous recombination / DNA damage response, signal transduction by p53 class mediator / negative regulation of neuron differentiation / histone acetyltransferase complex / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / positive regulation of G1/S transition of mitotic cell cycle / canonical Wnt signaling pathway / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / cellular response to glucose starvation / long-term memory / positive regulation of autophagy / histone acetyltransferase activity / extrinsic apoptotic signaling pathway in absence of ligand / histone acetyltransferase / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / tumor necrosis factor-mediated signaling pathway / FLT3 Signaling / negative regulation of cell migration / cellular response to nerve growth factor stimulus / positive regulation of erythrocyte differentiation / transcription coregulator binding / cellular response to glucose stimulus / RNA polymerase II transcription regulatory region sequence-specific DNA binding / MAPK6/MAPK4 signaling / protein destabilization / protein modification process / negative regulation of canonical Wnt signaling pathway / chromatin DNA binding / cellular response to virus / PML body / beta-catenin binding / transcription coactivator binding / positive regulation of DNA-binding transcription factor activity / DNA-binding transcription repressor activity, RNA polymerase II-specific類似検索 - 分子機能 Coactivator CBP, KIX domain / FOXO protein, KIX-binding domain / KIX-binding domain of forkhead box O, CR2 / FOXO protein, transactivation domain / Transactivation domain of FOXO protein family / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 ...Coactivator CBP, KIX domain / FOXO protein, KIX-binding domain / KIX-binding domain of forkhead box O, CR2 / FOXO protein, transactivation domain / Transactivation domain of FOXO protein family / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Serum Albumin; Chain A, Domain 1 / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Nuclear receptor coactivator, interlocking / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Forkhead box protein O3 / Histone lysine acetyltransferase CREBBP類似検索 - 構成要素 |
---|
生物種 | Mus musculus (ハツカネズミ) Homo sapiens (ヒト) |
---|
手法 | 溶液NMR / simulated annealing |
---|
Model details | lowest energy, model 1 |
---|
データ登録者 | Wang, F. / Marshall, C.B. / Yamamoto, K. / Li, G.B. / Gasmi-Seabrook, G.M.C. / Okada, H. / Mak, T.W. / Ikura, M. |
---|
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2012 タイトル: Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. 著者: Wang, F. / Marshall, C.B. / Yamamoto, K. / Li, G.Y. / Gasmi-Seabrook, G.M. / Okada, H. / Mak, T.W. / Ikura, M. |
---|
履歴 | 登録 | 2012年3月6日 | 登録サイト: BMRB / 処理サイト: RCSB |
---|
改定 1.0 | 2012年5月16日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年6月14日 | Group: Data collection / Database references / Other カテゴリ: database_2 / pdbx_database_status / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_spectrometer.model |
---|
改定 1.2 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
---|
|
---|