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基本情報
登録情報 | データベース: PDB / ID: 2lgf | ||||||
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タイトル | Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin | ||||||
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![]() | METAL BINDING PROTEIN | ||||||
機能・相同性 | ![]() glycosphingolipid binding / sialic acid binding / oligosaccharide binding / : / : / positive regulation of cyclic-nucleotide phosphodiesterase activity / : / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / negative regulation of peptidyl-threonine phosphorylation / leukocyte tethering or rolling ...glycosphingolipid binding / sialic acid binding / oligosaccharide binding / : / : / positive regulation of cyclic-nucleotide phosphodiesterase activity / : / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / negative regulation of peptidyl-threonine phosphorylation / leukocyte tethering or rolling / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / CaM pathway / Cam-PDE 1 activation / Sodium/Calcium exchangers / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / Calmodulin induced events / positive regulation of peptidyl-threonine phosphorylation / positive regulation of ryanodine-sensitive calcium-release channel activity / Reduction of cytosolic Ca++ levels / Activation of Ca-permeable Kainate Receptor / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / positive regulation of DNA binding / Loss of phosphorylation of MECP2 at T308 / CREB1 phosphorylation through the activation of Adenylate Cyclase / CaMK IV-mediated phosphorylation of CREB / PKA activation / negative regulation of high voltage-gated calcium channel activity / Glycogen breakdown (glycogenolysis) / leukocyte cell-cell adhesion / CLEC7A (Dectin-1) induces NFAT activation / response to corticosterone / Activation of RAC1 downstream of NMDARs / organelle localization by membrane tethering / negative regulation of ryanodine-sensitive calcium-release channel activity / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / negative regulation of calcium ion export across plasma membrane / regulation of cardiac muscle cell action potential / presynaptic endocytosis / nitric-oxide synthase binding / Synthesis of IP3 and IP4 in the cytosol / regulation of cell communication by electrical coupling involved in cardiac conduction / Phase 0 - rapid depolarisation / calcineurin-mediated signaling / Negative regulation of NMDA receptor-mediated neuronal transmission / regulation of synaptic vesicle exocytosis / Unblocking of NMDA receptors, glutamate binding and activation / positive regulation of protein autophosphorylation / RHO GTPases activate PAKs / Ion transport by P-type ATPases / Uptake and function of anthrax toxins / regulation of ryanodine-sensitive calcium-release channel activity / Long-term potentiation / protein phosphatase activator activity / Calcineurin activates NFAT / adenylate cyclase binding / Regulation of MECP2 expression and activity / DARPP-32 events / catalytic complex / Smooth Muscle Contraction / regulation of synaptic vesicle endocytosis / detection of calcium ion / regulation of cardiac muscle contraction / positive regulation of protein serine/threonine kinase activity / RHO GTPases activate IQGAPs / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / calcium channel inhibitor activity / cellular response to interferon-beta / activation of adenylate cyclase activity / Protein methylation / presynaptic cytosol / Activation of AMPK downstream of NMDARs / phosphatidylinositol 3-kinase binding / Ion homeostasis / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of nitric-oxide synthase activity / eNOS activation / titin binding / enzyme regulator activity / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / sperm midpiece / voltage-gated potassium channel complex / regulation of calcium-mediated signaling / response to cytokine / calcium channel complex / substantia nigra development / FCERI mediated Ca+2 mobilization / response to amphetamine / Ras activation upon Ca2+ influx through NMDA receptor / regulation of heart rate / FCGR3A-mediated IL10 synthesis / nitric-oxide synthase regulator activity / calyx of Held / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / adenylate cyclase activator activity / secretory granule membrane / sarcomere / VEGFR2 mediated cell proliferation / regulation of cytokinesis 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR / torsion angle dynamics, simulated annealing | ||||||
Model details | lowest energy, model 1 | ||||||
![]() | Gifford, J.L. / Ishida, H. / Vogel, H.J. | ||||||
![]() | ![]() タイトル: Structural Insights into Calmodulin-regulated L-selectin Ectodomain Shedding. 著者: Gifford, J.L. / Ishida, H. / Vogel, H.J. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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-検証レポート
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-関連構造データ
類似構造データ | |
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その他のデータベース |
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 16650.273 Da / 分子数: 1 / 断片: sequence database residues 4-149 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() 遺伝子: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII 発現宿主: ![]() ![]() |
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#2: タンパク質・ペプチド | 分子量: 1834.344 Da / 分子数: 1 / 断片: sequence database residues 349-363 / 由来タイプ: 合成 / 由来: (合成) ![]() |
#3: 化合物 | ChemComp-CA / |
-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR実験 |
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試料調製
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試料 |
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試料状態 |
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-NMR測定
NMRスペクトロメーター | タイプ: Bruker Avance / 製造業者: Bruker / モデル: AVANCE / 磁場強度: 500 MHz |
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解析
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精密化 | 手法: torsion angle dynamics, simulated annealing / ソフトェア番号: 1 | |||||||||||||||||||||||||||||||||||||||
代表構造 | 選択基準: lowest energy | |||||||||||||||||||||||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 200 / 登録したコンフォーマーの数: 1 |